Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: A Novel Compound for Alcoholism Treatment: a Translational Strategy - Part II
Brief Summary:
Background:
Hormones are naturally occurring chemicals in the body. Ghrelin is a hormone that stimulates appetite. It may also stimulate alcohol cravings and use. Researchers want to learn more about alcohol cravings and test if a drug that blocks ghrelin lowers alcohol cravings.
Objective:
To test if the drug PF-05190457 decreases alcohol craving.
Eligibility:
People ages 18 65 who have:
Alcohol use disorder
No other serious medical problems
Woman must be postmenopausal or have had surgery to prevent pregnancy.
Design:
Participants will stay on the inpatient unit here at the Clinical Center for two 2-week stages, which will be separated by at least 2 days. The inpatient phase include:
Taking the study drug or placebo by mouth twice daily
Blood tests
Tasting several sweet solutions
Physical exams
Smokers will smoke cigarettes through a device that gives information about how they smoke a
cigarette.
Exposure to alcohol, water, and food cues in a bar-like room. Participants answer questions on a computer.
Blood pressure and heart rate are m