Clinical Trial: mp3 vs Apatos in Post-extractive Sockets

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional




Official Title: A Prospective Randomized-controlled Multicenter Clinical and Histological Study of Extraction Site Augmentation With mp3 vs. Apatos

Brief Summary:

The primary aim of the present multicenter randomized controlled trial was to evaluate and compare the shortterm clinical and histological changes of extraction sockets after ridge preservation procedures with changes of extraction sockets that healed naturally.

The secondary aim was to evaluate which, if any extraction socket characteristics could have affected tissue changes occurring at the augmented as well as naturally healed sites.

Recruitment and enrollment of patients were performed from June 2011 to June 2012 in five university centers/private practice:

  • University of Pisa;
  • University of Murcia;
  • University of Ancona;
  • Private practice, Dr. Di Felice;
  • University of Verona.

Randomization:

  1. extraction sockets with spontaneous healing;
  2. extraction sockets grafted with pre-hydrated collagenated cortico-cancellous porcine bone, with a particle size between 600 and 1000 μm;
  3. extraction sockets grafted with cortical porcine bone, with a particle size between 600 and 1000 μm.

Outcome Variables

  • Complications
  • Changes of ridge volume contour;
  • Vertical bone changes;
  • Buccal-Lingual Width;
  • Histomorphometric parameters.