Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title:
Brief Summary:
Background:
Recurrent aphthous stomatitis is a common phenomenon in Primary Medicine.Frequency of the phenomenon can be as high as 25% of the general population and the recurrence of the problem can be up to 50%.Different approaches for treatment are described: treatment with various natural vitamins , local ointments , disinfectant agents for local treatment , local antibiotic ointments , NSAID, local cortisone-steroids , and even medication on the basis of immune-depressants of the immune system and systematic steroids .
Methods:
A double-blind study of daily administration of sublingual Vitamin B12 tablets manufactured by Solgar (each tablet containing 1000 mcg. of Vitamin B12) opposed to placebo tablets.
Purpose of the research:
To investigate the effect of Vitamin B12 on the frequency of recurrent canker sores of the mouth (RAS).
Study hypothesis:
Treatment with vitamin B12 will reduce the recurrence rate and will diminish the symptomatology of RAS episodes.