Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Neuropsychological Effects of Immunosuppressive Treatment in Subjects With Aplastic Anemia
Brief Summary:
This study will use neuropsychological tests to look at nervous system side effects of Cyclosporine (CsA) in patients with aplastic anemia. CsA is used as part of an immunosuppressive regimen in treating severe aplastic anemia. The drug can produce nervous system side effects, such as tremor and, less commonly, insomnia, anxiety, headache, confusion or seizures. This study will look at effects of CsA on intellectual ability, depression, anxiety, attention, concentration, memory, perception, coordination, and thought processing in patients
Patients 15 years of age or older who have severe aplastic anemia may be eligible for this study if they:
Participants undergo neuropsychological testing. In addition, they provide blood samples and their clinical data are reviewed for things that may influence the interpretation of findings from the testing, such as results of blood tests, types of medications taken, number of transfusions required, etc. The procedures are as follows:
Before first dose of cyclosporine: