Clinical Trial: The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity
Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational
Official Title: The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity
Brief Summary:
Objectives:
- To study nutrition and immune system problems in people with urea cycle disorders.
- To study how people with urea cycle disorders and healthy volunteers respond to standard flu and/or hepatitis A vaccines.
- To compare differences in nutrition and immune systems of people with urea cycle disorders with that of healthy volunteers.
Eligibility:
- Healthy males and females at least 2 years of age who are able to travel to the National Institutes of Health hospital in Bethesda, MD
- Males and females at least 2 years of age who have a urea cycle disorder and are able to travel to the National Institutes of Health hospital in Bethesda, MD.
Design:
For Patients with urea cycle disorder:
- Participants will spend 2 to 3 days in the National Institutes of Health hospital for the following tests:
- A physical exam and review of medical history
- Food log for 3 days before the start of the study
- Blood tests
- 24-hour urine collection
- Resting metabolism test
- DEXA scan imaging study of bones and body fat
- Participants who are old enough to do certain tasks by themselves (like dressing and eating) can choose to have the following extra tests:
- 24-hour metabol