Clinical Trial: CADASIL Disease Discovery

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational



Official Title: CADASIL Disease Discovery

Brief Summary:

Cerebral autosomal dominant arteriopathy with subcortical infarct (CADASIL) is a lethal disease caused by a gene mutation that affects arteries in the brain. Symptoms include migraines, strokes, memory loss, and dementia. There are no treatments. Researchers want to study people who have CADASIL to learn more about it.

Objectives:

To learn more about CADASIL by studying people who have it.

Eligibility:

People ages 18-100 who were diagnosed with CADASIL in the past 5 years and can make their own decisions

Design:

Participants will be screened in another NIH protocol.

Participants will have 3 visits over 2 years. These may include:

  • Physical exam
  • Thinking and concentration tests
  • Blood tests
  • Skin biopsy: A small skin punch is removed from the arm or leg
  • Eye exam and eye imaging tests
  • Fluorescein angiogram: A catheter is placed in an arm vein. Dye is given through the catheter and travels

to the eyes.

  • EndoPAT: A small clamp on the fingertip measures blood volume.
  • Cardio-ankle vascular index (CAVI): Artery stiffness is tested with blood pressure cuffs on the arms and

legs. Soft electrodes on the skin meas