Clinical Trial: Natural History of Noncirrhotic Portal Hypertension

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational



Official Title: Natural History of Noncirrhotic Portal Hypertension

Brief Summary:

Background:

- Noncirrhotic Portal Hypertension (NCPH) is caused by liver diseases that increase pressure in the blood vessels of the liver. It seems to start slowly and not have many warning signs. Many people may not even know that they have a liver disease. There are no specific treatments for NCPH.

Objectives:

- To learn more about how NCPH develops over time.

Eligibility:

- People age 12 and older who have NCPH or are at risk for getting it. In the past year, they cannot have had other types of liver disease that typically result in cirrhosis, liver cancer, or active substance abuse.

Design:

  • Participants will have 2 screening visits.
  • Visit 1: to see if they have or may develop NCPH.
  • Medical history
  • Physical exam
  • Urine and stool studies
  • Abdominal ultrasound
  • Fibroscan. Sound waves measure liver stiffness.

<TAB>- Visit 2:

  • Blood tests
  • Abdominal MRI
  • Echocardiogram
  • Questionnaire
  • Liver blood vessel pressure (hepatic venous portal gradient (HVPG)) measurement. This is done with a small tube inserted in a neck vein.
  • They may have a