Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional
Official Title: 99mTc-rhAnnexin V-128 Imaging of Apoptosis and Cardiotoxicity in Relationship to Ventricular Function in Patients With Early Stage Breast Cancer Receiving Doxorubicin-Based Chemotherapy
Brief Summary:
The changes to the heart can be evaluated during the course of the chemotherapy with cardiac magnetic resonance imaging (CMRI) and left ventricular (LV) nuclear scans to look at left ventricular ejection fraction (LVEF). Serial LVEF evaluation can detect cardiotoxicity, usually after cardiac damage is present and most likely irreversible. Each patient's sensitivity to the chemotherapy is different.
The study is being done to assess the ability of the radiotracer 99mTc-rhAnnexin V-128 to image the cell damage from apoptosis, or cell death, in the heart from the effects of the chemotherapy. This may allow doctors to identify patients developing cardiotoxicity in the future. These patients may then benefit from changes in chemotherapy with dose alterations or changes to alternative drugs.