Clinical Trial: Transcranial Magnetic Stimulation for Focal Hand Dystonia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational




Official Title: Gamma Frequency Transcranial Magnetic Stimulation in Dystonia

Brief Summary:

Background:

  • The brain has natural electrical rhythms of brain activities. These rhythms may be different in people with movement disorders, such as dystonia (involuntary muscle movement, cramps, or tremors). Understanding these rhythms may provide more information about movement disorders.
  • Focal hand dystonia, also known as "writer's cramp" or "musician's cramp," is a painful condition that affects the hand and arm muscles. Researchers want to use transcranial magnetic stimulation (TMS) to study brain rhythms in people with and without focal hand dystonia.

Objectives:

- To better understand brain rhythms involved in focal hand dystonia.

Eligibility:

  • Individuals between 18 and 70 years of age who are right-handed and have focal hand dystonia.
  • Healthy right-handed volunteers between 18 and 60 years of age.

Design:

  • Participants will be screened with a physical exam and medical history.
  • This study includes two tests: a pilot test and a main test. The pilot test will determine the frequency of TMS that will be used in the main test. Participants may be in one or both tests. Each test requires a single outpatient visit that will last up to 5 hours.
  • Participants will have a base test to see how their muscles respond to TMS. This will look at the electrical activity of the muscles. Participants will have a wire coil held