Study Status: RECRUITING
Recruit Status: RECRUITING
Study Type: INTERVENTIONAL
Official Title: Study Protocol: The Effect of Blood Pressure on Cerebral Blood Flow in Comatose Out-of-hospital Cardiac Arrest Patients
Brief Summary: Comatose patients that are admitted to an intensive care unit after out-of-hospital cardiac arrest (OCHA) have a high mortality, particularly due to hypoxic-ischemic neurologic injury.
These patients often require vasopressors to maintain mean arterial pressure (MAP), but it is unclear what level of MAP should be aimed for.
The objective of the study is to evaluate whether cerebral blood flow (CBF) and cerebral metabolism can be increased by maintaining MAP at a higher level than that used in clinical practice.
The study will include twenty comatose patients within two days following resuscitation after OCHA.
In the study, MAP is adjusted by infusion of noradrenaline, to a low, moderate, and high level for a short time.
The low level of MAP used in the study, corresponds to the level aimed for in clinical practice.
The CBF will be evaluated on the neck using ultrasound.