Study Status: COMPLETED
Recruit Status: COMPLETED
Study Type: INTERVENTIONAL
Official Title: Ketogenic Diet (KD) in Alcoholism
Brief Summary:
Background:
A ketogenic diet (KD) is high in fat and low in carbohydrates.
Research has shown that a KD can lessen tremor in animals withdrawing from alcohol.
KD can also help people who have difficulties with thinking, sleep, and mood.
Researchers want to see if KD can lessen symptoms of alcohol withdrawal in people with alcohol use disorder.
Objective:<TAB>
To test the effects of a ketogenic diet on alcohol withdrawal symptoms.
Eligibility:
Adults 18 years or older who are moderate or severe alcohol drinkers and are seeking treatment for alcohol use.
They must be in the NIAAA inpatient alcohol treatment program.
Design:
Participants will be screened under another protocol.
They will have a medical and psychiatric history, physical exam, and blood and urine tests.
Participants will have a breath test for alcohol.
The study will be done in a 3-week stay in the clinic.
Participants will get either a KD or Standard American diet.
Participants will have breathalyzer, blood, and urine tests.
Participants will have magnetic resonance imaging (MRI) scans.
The scanner is a cylinder in a magnetic field.
They will lie on a table that slides in and out of the cylinder.
They will do tasks on a computer during the scan.
Participants will have tests of thinking, memory, and attention.
Participants will have their sleeping and waking measured.
They will wear a device like a headband held in place with elastic straps.
Several electrodes will be placed on the body.
Participants will have heart tests.
Participants will wear an activity monitor on the wrist.
After the clinic stay, participants will be called by phone about 5 times over 3 months.