Clinical Trial: Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia

Brief Summary:

Background:

Idiopathic CD4+ lymphocytopenia (ICL) is a condition in which there is a decreased level of CD4+ lymphocytes (a type of white blood cell), which can lead to opportunistic infections or autoimmune disorders and diseases.

Objectives:

To characterize the natural history with regard to CD4+ T cell count and onset of infection, malignancy, and autoimmunity.
To describe the immunological status of patients affected by ICL while providing the best possible standard therapy to eradicate opportunistic infections.
To establish the timeline of CD4 lymphocytopenia, with particular focus on defining subgroups of patients according to the decline, stabilization, or rise of CD4+ T cell counts over time.
To characterize the opportunistic infections that occur in ICL patients at microbiologic and molecular levels.
To characterize the immunophenotype and possible genetic immunodeficiency causes of ICL.
To determine whether measurable immunologic parameters correlate with the development of opportunistic infections or other comorbidities such as lymphoma in patients with ICL.
To determine whether there is any association between ICL and autoimmunity.
To determine CD4+ T cell turnover, survival, functionality, and cytokine responsiveness in ICL patients.

Eligibility: