Clinical Trial: Severe and Cerebral Malaria Investigated Through Host Metabolomics

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

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Official Title: Microvascular and Metabolic Dysregulation in the Pathogenesis of Severe and Cerebral Malaria Investigated Through Host Metabolomics

Brief Summary:

• The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.
• Despite treatment between 10-30% of patients with severe malaria die.
• Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.
• Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.