Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabis
Brief Summary: Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of orally consumed intact cannabis (e.g., cannabis-containing brownies). Careful analysis of oral cannabis dose effects on these parameters is required to determine the level and duration of biological cannabinoid exposure and associated subjective, cardiovascular and cognitive effects. The present study will evaluate the detection of cannabinoids in oral fluid, plasma, hair, and urine for up to 9 days following consumption of oral cannabis (10mg, 25mg, or 50mg THC). In addition, we will conduct subjective, behavioral, and cognitive performance assessments to evaluate the time course of the consequences of oral cannabis ingestion among study participants. The outcomes of the study will extend scientific knowledge about the behavioral pharmacology and toxicology of oral cannabis and can inform policies regarding clinical, workplace and roadside drug testing programs.