Clinical Trial: Mexiletine and Non Dystrophic Myotonias

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional



Official Title: Efficacy and Safety of Mexiletine in Non-dystrophic Myotonias

Brief Summary:

Treatment strategies in non-dystrophic myotonias are based on selective case reports, clinical experience and theoretical benefit. Presently, the most promising antimyotonic medication is mexiletine (MEX) but its manufacturing was stopped. The proposed randomized, double-blind, placebo-controlled, crossover trial is designed to:

  1. study the safety and efficacy of mexiletine for the treatment of non-dystrophic myotonias
  2. validate electromyographic tests as a standardized outcome measure of myotonia
  3. assess the reliability and validity of a new clinical rating scale for myotonia