Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Impact of Trimethoprim-sulfamethoxazole Prophylaxis on Malaria Infection and Immunity in Children in Uganda
Brief Summary:
Background:
- Malaria is a disease that affects many children and adults in Uganda and Africa. If it is not treated, it can make some people severely ill. TMP-SMX (Trade names Bactrim, Septrin) is a drug that is given to children born to HIV-positive mothers to help prevent infection. Studies have shown that TMP-SMX also may kill malaria infection in the very early stages of infection in the body, which may positively impact the way the body can fight malaria infection. Researchers want to know if giving TMP-SMX for 6 months longer than usual helps children fight malaria better in this way.
Objective:
- To find out if taking TMP-SMX for longer than usual helps fight off malaria in infants.
Eligibility:
- Infants 0-6 weeks of age who are HIV negative.
Design: