Clinical Trial: Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment in Malian Children

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational



Official Title: Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment

Brief Summary:

Background:

- The disease malaria can cause very serious health problems. Researchers want to see if malaria affects the way T cells and vaccines work in the body. If it does, they may need to give malaria treatments before vaccines. They want to check the T cells in children who do or do not get antimalarial treatment.

Objectives:

- To study the effect of blood stage malaria on T cell suppression and vaccine responses. To describe markers of T cell suppression in children who do or do not receive antimalarial treatment.

Eligibility:

- Children ages 12 59 months living near Ouelessebougou in Mali. They must have no serious illness.

Design:

  • Participants will be screened with medical history and physical exam.
  • Some participants will get a course of antimalarial tablets. Some will not. This will be decided at random.
  • Participants will have monthly visits for up to a year. They will have blood tests at each visit.