Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational [Patient Registry]
Official Title: DIagnostics, RBC Levels of n-3 Fatty Acids and Serum Vitamin D in Patients With Out-of-Hospital Cardiac Arrest (OHCA)
Brief Summary:
Sudden cardiac death (SCD) accounts for approximately 15 percent of the total mortality in industrialized countries, and most commonly results from cardiac arrest due to ventricular fibrillation (VF). VF can appear both with identifiable heart disease and as an idiopathic arrhythmia. The most commonly underlying heart disease associated with out-of-hospital cardiac arrest (OHCA) is coronary artery disease (CAD).
In this study the investigators intend to give a thorough description of the study population based on demographic data, clinical information, medical history and biochemical parameters. The investigators plan to assess the total number of OHCA cases among patients reported to the ambulance service in the local region during the study period, and determine the proportion with documented VF. Next the investigators need to evaluate the clinical baseline profile of those included in the study as compared to that of the total VF population. High sensitivity cardiac Troponin T cTnT) and brain natriuretic peptide (BNP) will be added to the baseline data for further classification of the included SCA patients.
The main aim of the study will be to evaluate the diagnostic value of copeptin in the setting of sudden cardiac arrest (SCA).
As a second aim the investigators intend to evaluate the association between VF and the content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in red blood cells.
Furthermore, as vitamin D is associated with n-3 fatty polyunsaturated acids (n-3 PUFAs) in the diet, the third aim will be to assess the association between 25-hydroxy (OH)-vitamin D and VF. Matched MI patients will be selected for comparison.