Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Intravitreal Tissue Plasminogen Activator (tPA) And Perfluoropropane (C3F8) for the Treatment of Neovascular Age-related Macular Degeneration With Associated Submacular Haemorrhage (TAPAS): a Multi-ce
Brief Summary:
This study will recruit patients who have recently had a submacular haemorrhage (bleed under the part of the retina responsible for detailed vision), as a complication of wet age-related macular degeneration (wet AMD). Wet AMD is a very common disease where abnormal blood vessels form under the retina and leak, causing a significant reduction in vision.
The study will investigate treatment of the bleed with various combinations of the two drugs: tissue plasminogen activator (tPA) - designed to dissolve the blood clot; and perfluoropropane (C3F8) - designed to shift the blood clot away from the central part of the retina (the macula). tPA is a commonly used 'clot-buster' drug for the treatment of stroke. C3F8 is a gas commonly used in eye surgery. Patients recruited will be divided into four groups: control group that receive none of the above drugs; one group that receives only tPA; one group that receives only C3F8; and one group that receives both.
All patients will receive the current gold standard treatment for wet AMD, ranibizumab (Lucentis®).
The aim of the study is to improve vision in a condition, which left untreated, would cause severe visual loss.