Clinical Trial: A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional



Official Title: A Pilot Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma

Brief Summary:

This study will test if giving topotecan directly into the blood vessel of the eye will improve the treatment of retinoblastoma. This method is referred to as "selective intra-ophthalmic artery chemotherapy" (SIOAC).

The goals of this study are:

  • To find out if topotecan is an effective treatment for retinoblastoma when delivered directly to the ophthalmic artery (SIOAC delivery)
  • To find out what kind of effects (good and bad) can be expected when topotecan is given by SIOAC
  • To assess visual pathway function before and after the study therapy
  • To learn more about the pharmacology (how your body handles the drug) of topotecan when delivered directly to the ophthalmic artery