Clinical Trial: Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Brief Summary:
Hypotheses:
- The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular, among young children diagnosed with optic nerve hypoplasia (ONH) is higher than is commonly thought.
- Early treatment of children with ONH and GH-deficiency can prevent adverse outcomes.
Aims:
- Determine the prevalence and types of endocrinopathies in children diagnosed with ONH.
- Correlate endocrine outcome with radiographic, ocular, and developmental findings in children with ONH.
- Examine the effect of GH treatment on growth and obesity in children with ONH, GH-deficiency, and either subnormal or normal growth compared to children with ONH that are not GH-deficient.
- Compare growth outcomes between children with isolated GH-deficiency and those with multiple hormone deficiencies.