Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: The Role of Endothelin-1 in Sickle Cell Disease
Brief Summary: The primary goal of the study is to determine the safety and tolerability of ambrisentan. It is also expected that ambrisentan will improve blood flow in the lungs, decrease inflammation, and reduce pain in sickle cell patients. An additional goal is to evaluate the use of select biomarkers in evaluating sickle nephropathy.