Clinical Trial: A Phase I Study of TNP-470 in the Treatment of AIDS-Associated Kaposi's Sarcoma

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional




Official Title: A Phase I Study of TNP-470 in the Treatment of AIDS-Associated Kaposi's Sarcoma

Brief Summary:

To assess toxicity and determine the MTD of intravenous TNP-470 administered weekly in patients with AIDS-related Kaposi's sarcoma. To assess pharmacokinetics and tumor response of the drug.

Since evidence shows that neovascularization is important in the development of Kaposi's sarcoma, drugs that inhibit angiogenesis, such as TNP-470, may be of benefit in patients with the disease.