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Ampullary (AM-poo-la-ree) cancer is a rare cancer that forms in an area of your digestive system called the ampulla of Vater. The ampulla of Vater is where your bile duct and pancreatic duct join and empty into your small intestine.
Ampullary cancer forms near many other parts of the digestive system, such as the liver, pancreas and small intestine. When ampullary cancer grows, it may affect these other organs.
Ampullary cancer treatment often involves extensive surgery to remove the cancer and a large margin of healthy tissue.