Disease: Vasculitis

Overview

Vasculitis is inflammation of your blood vessels. It causes changes in the blood vessel walls, including thickening, weakening, narrowing or scarring. These changes can restrict blood flow, resulting in organ and tissue damage.

There are many types of vasculitis, and most of them are rare. Vasculitis might affect just one organ, or several. The condition can be short term (acute) or long lasting (chronic).

Vasculitis can affect anyone, though some types are more common among certain groups. Depending on the type you have, you may improve without treatment. Some types require medications to control the inflammation and prevent flare-ups.

Vasculitis is also known as angiitis and arteritis.

Source: http://www.mayoclinic.com

Symptoms

The signs and symptoms of vasculitis vary greatly. They're often related to decreased blood flow throughout the body.

General signs and symptoms common to most vasculitis types

General signs and symptoms of vasculitis include:

  • Fever
  • Headache
  • Fatigue
  • Weight loss
  • General aches and pains
  • Night sweats
  • Rash
  • Nerve problems, such as numbness or weakness

Signs and symptoms for specific types of vasculitis

Other signs and symptoms are related only to certain types of vasculitis. The symptoms can develop early and rapidly or in later stages of the disease.

  • Behcet's (beh-CHETS) disease. This condition causes inflammation of your arteries and veins. Signs and symptoms include mouth and genital ulcers, eye inflammation, and acne-like skin lesions.
  • Buerger's disease. This condition causes inflammation and clots in the blood vessels of your hands and feet, resulting in pain and ulcers in these areas. Rarely, Buerger's disease can affect blood vessels in the abdomen, brain and heart. It is also called thromboangiitis (throm-boe-an-jee-I-tis) obliterans.
  • Churg-Strauss syndrome (Eosinophilic granulomatosis with polyangiitis). This condition is very rare. It mainly affects the lungs, skin, kidneys, heart and nerves in your limbs. Signs and symptoms vary greatly and include asthma, skin changes, nerve pain and nasal allergies.
  • Cryoglobulinemia. This condition results from abnormal proteins in the blood. Signs and symptoms include rash, joint pain, weakness, and numbness or tingling.
  • Giant cell arteritis. This condition is an inflammation of the arteries in your head, especially at the temples. Giant cell arteritis can cause headaches, scalp tenderness, jaw pain, blurred or double vision, and even blindness. It is also called temporal arteritis.
  • Granulomatosis with polyangiitis. This condition causes inflammation of the blood vessels in your nose, sinuses, throat, lungs and kidneys. Signs and symptoms include nasal stuffiness, sinus infections, nosebleeds and possibly coughing up blood. But most people don't have noticeable symptoms until the damage is more advanced.
  • Henoch-Schonlein purpura (IgA vasculitis). This condition is more common in children than in adults, and causes inflammation of the smallest blood vessels (capillaries) of your skin, joints, bowel and kidneys. Signs and symptoms include abdominal pain, blood in the urine, joint pain, and a rash on your buttocks or lower legs.
  • Hypersensitivity vasculitis. Sometimes called allergic vasculitis, the primary sign of this condition is red spots on your skin, usually on your lower legs. It can be triggered by an infection or an adverse reaction to medicine.
  • Kawasaki disease. This condition most often affects children younger than age 5. Signs and symptoms include fever, rash and redness of the eyes. It is also called mucocutaneous lymph node syndrome.
  • Microscopic polyangiitis. This form of vasculitis affects small blood vessels, usually those in the kidneys, lungs or nerves. You may develop abdominal pain and a rash, fever, muscle pain and weight loss. If the lungs are affected, you may cough up blood.
  • Polyarteritis nodosa. This form of vasculitis usually affects the kidneys, the digestive tract, the nerves and the skin. Signs and symptoms include a rash, general malaise, weight loss, muscle and joint pain, abdominal pain after eating, high blood pressure, muscle pain and weakness, and kidney problems.
  • Takayasu's (tah-kah-YAH-sooz) arteritis. This form of vasculitis affects the larger arteries in the body, including the aorta. Signs and symptoms include joint pain, loss of pulse, high blood pressure, night sweats, fever, general malaise, appetite loss, headaches and visual changes.

When to see a doctor

Make an appointment with your doctor if you have any signs or symptoms that worry you. Some types of vasculitis can worsen quickly, so early diagnosis is key to getting effective treatment.

Source: http://www.mayoclinic.com

Causes

The exact cause of vasculitis isn't fully understood. Some types are related to a person's genetic makeup. Others result from the immune system attacking blood vessel cells by mistake. Possible triggers for this immune system reaction include:

  • Infections, such as hepatitis B and hepatitis C
  • Blood cancers
  • Immune system diseases, such as rheumatoid arthritis, lupus and scleroderma
  • Reactions to certain drugs

Blood vessels affected by vasculitis may bleed or become inflamed. Inflammation can cause the layers of the blood vessel wall to thicken. This narrows the blood vessels, reducing the amount of blood — and therefore oxygen and vital nutrients — that reaches your body's tissues and organs.

Source: http://www.mayoclinic.com

Diagnosis

Your doctor likely will start by taking your medical history and performing a physical exam. He or she may have you undergo one or more diagnostic tests and procedures to either rule out other conditions that mimic vasculitis or diagnose vasculitis. Tests and procedures might include:

  • Blood tests. These tests look for signs of inflammation, such as a high level of C-reactive protein. A complete blood cell count can tell whether you have enough red blood cells. Blood tests that look for certain antibodies — such as the anti-neutrophil cytoplasmic antibodies test — can help diagnose vasculitis.
  • Urine tests. These tests may reveal whether your urine contains red blood cells or has too much protein, which can signal a medical problem.
  • Imaging tests. Noninvasive imaging techniques can help determine what blood vessels and organs are affected. They can also help the doctor monitor whether you are responding to treatment. Imaging tests for vasculitis include X-rays, ultrasound, computerized tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET).
  • X-rays of your blood vessels (angiography). During this procedure, a flexible catheter, resembling a thin straw, is inserted into a large artery or vein. A special dye (contrast medium) is then injected into the catheter, and X-rays are taken as the dye fills the artery or vein. The outlines of your blood vessels are visible on the resulting X-rays.
  • Biopsy. This is a surgical procedure in which your doctor removes a small sample of tissue from the affected area of your body. Your doctor then examines this tissue for signs of vasculitis.

Source: http://www.mayoclinic.com

Complications

Vasculitis complications depend on the type and severity of your condition. Or they may be related to side effects of the prescription medications you use to treat the condition. Complications of vasculitis include:

  • Organ damage. Some types of vasculitis can be severe, causing damage to major organs.
  • Blood clots and aneurysms. A blood clot may form in a blood vessel, obstructing blood flow. Rarely, vasculitis will cause a blood vessel to weaken and bulge, forming an aneurysm (AN-yoo-riz-um).
  • Vision loss or blindness. This is a possible complication of untreated giant cell arteritis.
  • Infections. These include serious and life-threatening conditions, such as pneumonia and blood infection (sepsis).

Source: http://www.mayoclinic.com

Coping and support

One of your greatest challenges of living with vasculitis may be coping with side effects of your medication. The following suggestions may help:

  • Understand your condition. Learn everything you can about vasculitis and its treatment. Know the possible side effects of the drugs you take, and tell your doctor about any changes in your health.
  • Follow your treatment plan. Your treatment plan may include seeing your doctor regularly, undergoing more tests and checking your blood pressure.
  • Choose a healthy diet. Eating well can help prevent potential problems that can result from your medications, such as thinning bones, high blood pressure and diabetes. Choose a diet that emphasizes fresh fruits and vegetables, whole grains, low-fat dairy products, and lean meats and fish. If you're taking a corticosteroid drug, ask your doctor if you need to take a vitamin D or calcium supplement.
  • Get routine vaccinations. Keeping up to date on vaccinations, such as for the flu and pneumonia, can help prevent problems that can result from your medications, such as infection. Talk to your doctor about vaccinations.
  • Exercise most days of the week. Regular aerobic exercise, such as walking, can help prevent bone loss, high blood pressure and diabetes that can be associated with taking corticosteroids. It also benefits your heart and lungs. In addition, many people find that exercise improves their mood and overall sense of well-being. If you're not used to exercising, start out slowly and build up gradually. Your doctor can help you plan an exercise program that's right for you.
  • Maintain a strong support system. Family and friends can help you as you cope with this condition. If you think it would be helpful to talk with other people who are living with vasculitis, ask a member of your health care team about connecting with a support group.

Source: http://www.mayoclinic.com

Risk factors

Vasculitis can occur in any sex or race or at any age. But some factors can increase the risk, such as:

  • Smoking
  • Having chronic hepatitis B or C infections
  • Having some types of autoimmune conditions, including rheumatoid arthritis, scleroderma or lupus

Source: http://www.mayoclinic.com

Health Services in Toronto

Define Common Diseases

Welcome to WebHealthNetwork, here you can find information, definitaions and treatement options for most common diseases, sicknesses, illnesses and medical conditions. Find what diseases you have quick and now.