Undifferentiated pleomorphic sarcoma (UPS), formerly referred to as malignant fibrous histiocytoma, is a type of soft tissue cancer. The word "undifferentiated" in undifferentiated pleomorphic sarcoma means that the cells don't resemble the body tissues in which they develop. The cancer is called pleomorphic (plee-o-MOR-fik) because the cells grow in multiple shapes and sizes.
While sarcomas are not common tumors, they do represent one of the most common soft tissue malignancies in adults. Soft tissue sarcomas can develop in blood vessels and in deep skin, fat, muscle, fibrous or nerve tissues.
In particular, UPS usually occurs in the arms or legs, and somewhat less often in the area behind the abdominal cavity (retroperitoneum). The cancer typically becomes quite large over a period of weeks or months, sometimes growing quite rapidly. In most cases, only a rapidly growing UPS causes noticeable pain. Although it tends to grow locally, the cancer can spread to other locations in the body, most often the lungs.
Undifferentiated pleomorphic sarcoma is called a diagnosis of exclusion, meaning it's agreed upon when other diagnoses have been ruled out; it represents less than 5 percent of adult sarcomas.
Source: http://www.mayoclinic.com
Make an appointment with a doctor if you develop any signs or symptoms that seem unusual or that worry you:
Most often these signs and symptoms come from some other issue than sarcoma, but consult with your doctor regardless.
Source: http://www.mayoclinic.com
Although the causes of UPS are largely unknown, a small percentage (less than 2 to 3 percent) develops at the site of previous radiation therapy. In very rare cases, the sarcoma can also develop in or around chronic ulcers or tissue scarring. A specific cause isn't often identified for most UPS.
Source: http://www.mayoclinic.com
Initial evaluation for a suspected undifferentiated pleomorphic sarcoma usually starts with a history of when you first noticed the mass and how quickly it's been growing, as well as a physical examination. Your physical exam should focus on the current size and depth of the mass, whether it's connected to nearby normal tissues, and any signs of associated swelling or nerve damage.
Your doctors will want to check whether your mass is one of several much more common benign conditions, such as soft tissue tumors (for example, lipomas). Other malignant tumors should also be ruled out, including lymphoma, melanoma, carcinoma that has metastasized, or one of several other sarcomas.
Because benign soft tissue tumors are so much more common than undifferentiated pleomorphic sarcoma or other malignant soft tissue sarcomas, it can be challenging to assess which soft tissue masses call for further evaluation. Published criteria for urgent referral of a patient with a soft tissue lesion focus on three aspects:
Also, deeper lying masses are more likely to be sarcomas, as are lumps that redevelop after being surgically removed. The more of these clinical features exist, the greater the chance of malignancy. Increasing size is the strongest individual indicator.
In almost all instances your doctor will likely recommend you undergo diagnostic tests, including:
Again, if undifferentiated pleomorphic sarcoma is suspected, it's often best to seek care at a medical center that sees many people with this type of cancer. Experienced doctors will select the best biopsy technique to ensure proper surgical treatment and planning.
In the lab, a doctor trained in analyzing body tissues (pathologist) examines the tissue sample for signs of cancer. The pathologist also analyzes the sample to understand the type of cancer and to determine whether the cancer is aggressive.
Source: http://www.mayoclinic.com
No alternative treatments have been found helpful in treating undifferentiated pleomorphic sarcoma. But some complementary and alternative treatments may relieve the symptoms you experience due to cancer or cancer treatment.
Alternative treatments that may help relieve symptoms include:
Resources such as the American Cancer Society and the National Cancer Institute offer more information on complementary and alternative treatment options as well as further advice on symptom relief.
Source: http://www.mayoclinic.com
A diagnosis of cancer such as undifferentiated pleomorphic sarcoma can be overwhelming. With time you'll find ways to cope with the distress and uncertainty of cancer. Until then, you may find it helps to:
Find someone to talk with. Find a good listener who is willing to listen to you talk about your hopes and fears. This may be a friend or family member. The concern and understanding of a counselor, medical social worker, clergy member or cancer support group also may be helpful.
Ask your doctor about support groups in your area. Or check your phone book, library or a cancer organization, such as the National Cancer Institute or the American Cancer Society.
Source: http://www.mayoclinic.com
Most undifferentiated pleomorphic sarcomas develop in people with no known risk factors. However, some factors may increase their likelihood, including radiation, a damaged lymph system and exposure to certain chemicals.
Again, most people who develop undifferentiated pleomorphic sarcoma have no known risk factors, and many people who have risk factors never develop the cancer.
Source: http://www.mayoclinic.com
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