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Membranous nephropathy (MEM-bruh-nus nuh-FROP-uh-thee) occurs when the small blood vessels in the kidney (glomeruli), which filter wastes from the blood, become inflamed and thickened. As a result, proteins leak from the damaged blood vessels into the urine (proteinuria). For many, loss of these proteins eventually causes signs and symptoms known as nephrotic syndrome.
In mild cases, membranous nephropathy may get better on its own, without any treatment. As protein leakage increases, so does the risk of long-term kidney damage. In many, the disease ultimately leads to kidney failure. There's no absolute cure for membranous nephropathy, but successful treatment can lead to remission of proteinuria and a good long-term outlook.
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Membranous nephropathy usually develops gradually, so you may not suspect that anything is wrong. As you lose protein from your blood, swelling in your legs and ankles and weight gain from excess fluid can occur. Some people experience lots of swelling from the very beginning of the disease, and others may not have any severe symptoms until they have advanced kidney disease.
Signs and symptoms of membranous nephropathy include:
If you have blood in your urine, persistent swelling in your legs and ankles, or increased blood pressure, make an appointment to see a doctor.
Source: http://www.mayoclinic.com
In a majority of cases of membranous nephropathy, evidence of autoimmune activity can be found. Your body's immune system mistakes some of your own tissues as foreign and attacks them with autoantibodies. These autoantibodies can damage your kidney's filtering systems (glomeruli).
Sometimes membranous nephropathy is brought on by other causes, notably:
Membranous nephropathy may also occur along with other kidney diseases, such as diabetic nephropathy and rapidly progressive (crescentic) glomerulonephritis.
Source: http://www.mayoclinic.com
At Mayo Clinic, we take the time to listen, to find answers and to provide you the best care.
To diagnose membranous nephropathy, your doctor may start with a detailed medical history and a physical exam. Your doctor may also recommend certain tests to identify possible causes and to determine how well your kidneys are working. These tests might include:
In some cases, membranous nephropathy occurs without any noticeable symptoms, and your doctor may discover the condition when the results of a routine urine test (urinalysis) show elevated protein levels in your urine (proteinuria).
Source: http://www.mayoclinic.com
Complications associated with membranous nephropathy include:
Source: http://www.mayoclinic.com
Talk to your doctor about how to reduce your chances of developing kidney disease. Your doctor may suggest that you:
Source: http://www.mayoclinic.com
Factors that can increase your risk of membranous nephropathy include:
Source: http://www.mayoclinic.com
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