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Takayasu's arteritis (tah-kah-YAH-sooz ahr-tuh-RIE-tis) is a rare type of vasculitis, a group of disorders that cause blood vessel inflammation. In Takayasu's arteritis, the inflammation primarily damages the aorta — the large artery that carries blood from your heart to the rest of your body — and the aorta's main branches.
The disease can lead to blockages or narrowed arteries (stenosis) or abnormally dilated arteries (aneurysms). Takayasu's arteritis can also lead to arm or chest pain and high blood pressure and eventually to heart failure or stroke.
The goal of treatment is to relieve inflammation in the arteries and prevent potential complications. Even with early detection and treatment, however, Takayasu's arteritis can be challenging to manage.
Source: http://www.mayoclinic.com
Takayasu's arteritis symptoms often occur in two stages. In the first stage, you're likely to feel unwell with:
Not everyone has these early symptoms, however. It's possible for inflammation to damage arteries for years before you realize something is wrong.
Second-stage symptoms begin to develop when inflammation has caused arteries to narrow. At this point, there's less blood, oxygen and nutrients reaching your organs and tissues. These signs and symptoms may include:
If you have symptoms that might suggest Takayasu's arteritis, see your doctor. Many signs and symptoms of Takayasu's arteritis are similar to those of other conditions, which can make diagnosis challenging. Still, early detection of the disease is important for getting the most benefit from treatment and preventing complications.
If you've already been diagnosed with Takayasu's arteritis, keep in mind that the symptoms of a disease flare (recurrence) are often similar to those that occurred originally. Also pay attention to any new signs or symptoms. These may indicate either a disease flare or a complication of treatment.
Source: http://www.mayoclinic.com
In Takayasu's arteritis, the aorta and other major arteries, including those leading to your head and kidneys, become inflamed. Over time, the inflammation causes changes in these arteries, including thickening, narrowing and scarring. The result is reduced blood flow to vital tissues and organs, which can lead to serious complications and even death. Sometimes arteries become abnormally dilated, leading to aneurysms that may rupture.
Just what causes the initial inflammation in Takayasu's arteritis isn't known. It's likely that Takayasu's arteritis is an autoimmune disease in which your immune system malfunctions and attacks your own arteries as if they were foreign substances. The disease may be triggered by a virus or other infection.
Source: http://www.mayoclinic.com
At Mayo Clinic, we take the time to listen, to find answers and to provide you the best care.
Takayasu's arteritis can be challenging to detect, and some people go years without an accurate diagnosis. Your doctor may use some of the following steps and tests to help rule out other conditions that closely resemble Takayasu's arteritis and to confirm the diagnosis:
Unlike other types of vasculitis, the removal and analysis of tissue (biopsy) is not usually used to diagnose Takayasu's arteritis.
Because Takayasu's arteritis has a tendency to recur or flare up after being in remission for a while, these tests may be used not only for diagnosis but also for monitoring the progress of the disease and following up on effectiveness of treatment. Some of the medications used for Takayasu's arteritis may have potentially harmful effects over the long run, so it's important for you and your doctor to know when medication is beneficial and when its risks outweigh its benefits.
Source: http://www.mayoclinic.com
The severity of Takayasu's arteritis may vary. In some people, the condition remains mild and doesn't produce complications. But in others, extended or recurring cycles of inflammation and healing in the arteries can lead to one or more of the following:
A healthy pregnancy is possible for women with Takayasu's arteritis. However, the disease can affect your fertility and pregnancy. If you have Takayasu's arteritis and are planning on becoming pregnant, it's important to work with your doctor to develop a comprehensive plan to limit complications of pregnancy before you conceive. In addition, you'll be closely monitored throughout your pregnancy.
Source: http://www.mayoclinic.com
When Takayasu's arteritis is identified and treated early, the prognosis is usually good. One of your greatest challenges may be coping with side effects of your medication. The following suggestions may help:
Eat a healthy diet. Eating well can help prevent potential problems that may result from your condition and medications, such as high blood pressure, thinning bones and diabetes. Emphasize fresh fruits and vegetables, whole grains, and lean meats and fish while limiting salt, sugar and alcohol.
Be sure to get adequate amounts of calcium and vitamin D to help prevent osteoporosis, a primary side effect of treatment with corticosteroids. Ask your doctor what the proper amount of these nutrients is for you. If you find it hard to get calcium from your diet because you don't eat dairy products, for example, talk with your doctor about trying calcium supplements, which are often combined with vitamin D and may help combat thinning bones.
Eat a healthy diet. Eating well can help prevent potential problems that may result from your condition and medications, such as high blood pressure, thinning bones and diabetes. Emphasize fresh fruits and vegetables, whole grains, and lean meats and fish while limiting salt, sugar and alcohol.
Be sure to get adequate amounts of calcium and vitamin D to help prevent osteoporosis, a primary side effect of treatment with corticosteroids. Ask your doctor what the proper amount of these nutrients is for you. If you find it hard to get calcium from your diet because you don't eat dairy products, for example, talk with your doctor about trying calcium supplements, which are often combined with vitamin D and may help combat thinning bones.
Source: http://www.mayoclinic.com
Takayasu's arteritis primarily affects young girls and women in their 20s and 30s. The disorder occurs worldwide, but it's most common in Asian women.
Source: http://www.mayoclinic.com
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