Overview

Calciphylaxis (kal-sih-fuh-LAK-sis) is a serious, uncommon disease in which calcium accumulates in small blood vessels of the fat and skin tissues.

Calciphylaxis causes blood clots, painful skin ulcers and may cause serious infections that can lead to death. People who have calciphylaxis usually have kidney failure and are on dialysis or have had a kidney transplant. The condition can also occur in people without kidney disease.

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Symptoms

Signs and symptoms of calciphylaxis include:

• Large purple net-like patterns on skin
• Deep, very painful lumps that ulcerate creating open sores with black-brown crust that fails to heal — typically in skin areas with high fat content, such as the stomach and thigh, although they can occur anywhere
• Infections from wounds that don't heal

Source: http://www.mayoclinic.com

Causes

The exact cause of calciphylaxis is unknown, but recent studies have revealed that most people with the condition have abnormalities in blood-clotting factors. Blood-clotting factors are substances in your blood that help stop bleeding. These abnormalities can lead to small blood clots forming more often than they normally would.

In addition, people with calciphylaxis have an imbalance in the metabolism of calcium. This causes calcium to be deposited in the smallest parts of the arteries (arterioles), which eventually leads to the formation of blood clots in the arterioles. Blood clots can cause fat tissues and skin to be deprived of oxygen and nourishment.

Source: http://www.mayoclinic.com

Diagnosis

To determine if you have calciphylaxis, your doctor will review your medical history, assess your symptoms and do a physical exam. Tests may include:

• Skin biopsy. To diagnose calciphylaxis, your doctor may remove a small tissue sample from an area of affected skin for analysis.
• Blood tests. Blood samples measure a variety of substances in your blood — calcium, phosphorus, parathyroid hormone, abnormalities in blood-clotting factors, aluminum, urea nitrogen, creatinine and albumin, among others — to help your doctor assess your kidney and liver function.
• Imaging studies. X-rays may show branch-like calcium deposits in the blood vessels (vascular calcifications) that are common in calciphylaxis and in other advanced kidney diseases.

Read more about the blood urea nitrogen (BUN test), creatinine test and liver function tests.

Source: http://www.mayoclinic.com

Complications

Complications of calciphylaxis include:

• Severe pain
• Large, deep, nonhealing ulcers
• Blood infections
• Death, usually due to infection and multiorgan failure

Typically, the outlook for people with calciphylaxis isn't hopeful. Early detection and treatment is very important in helping to prevent serious infections.

Risk factors

Calciphylaxis most commonly affects people who have end-stage kidney failure. Possible risk factors include:

• Being female
• Obesity
• Diabetes
• Abnormalities in blood-clotting factors
• Long-term dialysis and sometimes kidney transplantation
• An imbalance of calcium, phosphorus and aluminum in the body
• Some medications, such as warfarin (Coumadin, Jantoven), calcium-binding agents or corticosteroids
• An overproduction of parathyroid hormone (PTH), which regulates the level of calcium and phosphorus in the body — a condition known as hyperparathyroidism
• Uremia, a toxic condition in which substances normally eliminated in the urine — such as calcium and phosphorus — build up in the body

Source: http://www.mayoclinic.com