Neuroblastoma is a cancer that develops from immature nerve cells found in several areas of the body.
Neuroblastoma most commonly arises in and around the adrenal glands, which have similar origins to nerve cells and sit atop the kidneys. However, neuroblastoma can also develop in other areas of the abdomen and in the chest, neck and near the spine, where groups of nerve cells exist.
Neuroblastoma most commonly affects children age 5 or younger, though it may rarely occur in older children.
Some forms of neuroblastoma go away on their own, while others may require multiple treatments. Your child's neuroblastoma treatment options will depend on several factors.
Neuroblastoma care at Mayo Clinic
Source: http://www.mayoclinic.com
Signs and symptoms of neuroblastoma vary depending on what part of the body is affected.
Neuroblastoma in the abdomen â the most common form â may cause signs and symptoms such as:
Neuroblastoma in the chest may cause signs and symptoms such as:
Other signs and symptoms that may indicate neuroblastoma include:
Contact your child's doctor if your child has any signs or symptoms that worry you. Mention any changes in your child's behavior or habits.
Source: http://www.mayoclinic.com
In general, cancer begins with a genetic mutation that allows normal, healthy cells to continue growing without responding to the signals to stop, which normal cells do. Cancer cells grow and multiply out of control. The accumulating abnormal cells form a mass (tumor).
Neuroblastoma begins in neuroblasts â immature nerve cells that a fetus makes as part of its development process.
As the fetus matures, neuroblasts eventually turn into nerve cells and fibers and the cells that make up the adrenal glands. Most neuroblasts mature by birth, though a small number of immature neuroblasts can be found in newborns. In most cases, these neuroblasts mature or disappear. Others, however, form a tumor â a neuroblastoma.
It isn't clear what causes the initial genetic mutation that leads to neuroblastoma.
Source: http://www.mayoclinic.com
Tests and procedures used to diagnose neuroblastoma include:
Once neuroblastoma is diagnosed, your child's doctor may order further testing to determine the extent of the cancer and whether it has spread to distant organs â a process called staging. Imaging tests used to stage cancer include X-rays, bone scans, and CT, MRI and MIBG scans, among others.
Using the information from those procedures, your child's doctor assigns a stage to the neuroblastoma. Stages of neuroblastoma include:
Source: http://www.mayoclinic.com
Source: http://www.mayoclinic.com
When your child is diagnosed with cancer, it's common to feel a range of emotions â from shock and disbelief to guilt and anger. In the midst of this emotional roller coaster, you're expected to make decisions about your child's treatment. It can be overwhelming.
If you're feeling lost, you might try to:
Maintain normalcy as much as possible. Small children can't understand what's happening to them as they undergo cancer treatment. To help your child cope, try to maintain a normal routine as much as possible.
Try to arrange appointments so that your child can have a set nap time each day. Have routine mealtimes. Allow time for play when your child feels up to it. If your child must spend time in the hospital, bring items from home that help him or her feel more comfortable.
Ask your health care team about other ways to comfort your child through his or her treatment. Some hospitals have recreation therapists or child-life workers who can give you more-specific ways to help your child cope.
Source: http://www.mayoclinic.com
Children with a family history of neuroblastoma may be more likely to develop the disease. Yet, familial neuroblastoma is thought to comprise a very small number of neuroblastoma cases. In most cases of neuroblastoma, a cause is never identified.
Source: http://www.mayoclinic.com
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