The rectum is the last several inches of the large intestine. It starts at the end of the final segment of your colon and ends when it reaches the short, narrow passage leading to the anus.
Cancer inside the rectum (rectal cancer) and cancer inside the colon (colon cancer) are often referred to together as "colorectal cancer."
While rectal and colon cancers are similar in many ways, their treatments are quite different. This is mainly because the rectum sits in a tight space, barely separated from other organs and structures in the pelvic cavity. As a result, complete surgical removal of rectal cancer is challenging and highly complex. Additional treatment is often needed before or after surgery â or both â to reduce the chance that the cancer will return.
In the past, long-term survival was uncommon for people with rectal cancer, even after extensive treatment. Thanks to treatment advances over the past 30 years, rectal cancer can now, in many cases, be cured.
Mayo Clinic's approach to rectal cancer care
Source: http://www.mayoclinic.com
Common symptoms include:
Make an appointment with your doctor if you have symptoms suggesting rectal cancer, particularly blood in your stool or unexplained weight loss.
Source: http://www.mayoclinic.com
Rectal cancer occurs when healthy cells in the rectum develop errors in their DNA. In most cases, the cause of these errors is unknown.
Healthy cells grow and divide in an orderly way to keep your body functioning normally. But when a cell's DNA is damaged and becomes cancerous, cells continue to divide â even when new cells aren't needed. As the cells accumulate, they form a tumor.
With time, the cancer cells can grow to invade and destroy normal tissue nearby. And cancerous cells can travel to other parts of the body.
In some families, gene mutations passed from parents to children increase the risk of colorectal cancer. These mutations are involved in only a small percentage of rectal cancers. Some genes linked to rectal cancer increase an individual's risk of developing the disease, but they don't make it inevitable.
Two well-defined genetic colorectal cancer syndromes are:
FAP, HNPCC and other, rarer inherited colorectal cancer syndromes can be detected through genetic testing. If you're concerned about your family's history of colon cancer, talk to your doctor about whether your family history suggests you have a risk of these conditions.
Source: http://www.mayoclinic.com
Rectal cancer is often diagnosed when a doctor orders tests to find the cause of rectal bleeding or iron deficiency anemia. A colonoscopy is the most accurate of these tests. In a colonoscopy, a doctor uses a thin, flexible, lighted tube with a video camera at its tip (a colonoscope) to view the inside of your colon and rectum.
Sometimes rectal cancer has no noticeable symptoms. People without symptoms may learn they have rectal cancer when they have a screening colonoscopy â that is, a colonoscopy recommended at age 50 for everyone with an average risk of colorectal cancer.
It's usually possible to remove small tissue samples (biopsies) from suspicious-looking areas during a colonoscopy. Laboratory analysis of this tissue helps pin down the diagnosis.
Once you are diagnosed with rectal cancer, the next step is to determine the cancer's extent (stage). Staging helps guide decisions about the most appropriate treatments for you. The following blood tests and imaging studies are involved in staging rectal cancer:
Rectal cancers fall into one of five possible stages (stage 0 through stage 4). The stages, in simplified form, are:
Staging also involves examining a sample of tissue taken from the tumor (a biopsy) to determine the tumor's grade. Low-grade tumors tend to grow and spread slowly. In contrast, high-grade tumors grow and spread quickly, so they may need more-aggressive treatment.
Source: http://www.mayoclinic.com
Talk to your doctor about when you should start getting screened for colorectal cancer. Guidelines generally recommend having your first colorectal cancer screening test at age 50. Your doctor may recommend more-frequent or earlier screening if you have other risk factors, such as a family history of colon or rectal cancer.
The most accurate screening test is a colonoscopy. In this test, a doctor examines the lining of your rectum and large intestine using a long, flexible tube with a tiny video camera at its tip (colonoscope). The colonoscope is inserted in the anus and advanced through the rectum and colon. As the scope's camera moves through the bowel, it sends a video of the rectal and colonic lining to a monitor the doctor sees. If a polyp or suspicious-looking area of tissue is found, the doctor can also take samples of tissue from these areas with instruments inserted in the colonoscope.
Source: http://www.mayoclinic.com
The characteristics and lifestyle factors that increase your risk of rectal cancer are the same as those that increase your risk of colon cancer. They include:
Source: http://www.mayoclinic.com
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