Dysphagia facts
What is dysphagia?
Dysphagia is the medical term for the symptom of difficulty swallowing, derived from the Latin and Greek words meaning difficulty eating.
Mechanism of swallowingSwallowing is a complex action.
Considering the complexity of swallowing, it is no wonder that swallowing, beginning with the contraction of the upper pharynx, has been "automated," meaning that no thought is required for swallowing once swallowing is initiated. Swallowing is controlled by automatic reflexes that involve nerves within the pharynx and esophagus as well as a swallowing center in the brain that is connected to the pharynx and esophagus by nerves. (A reflex is a mechanism that is used to control many organs. Reflexes require nerves within an organ such as the esophagus to sense what is happening in that organ and to send the information to other nerves in the wall of the organ or outside the organ. The information is processed in these other nerves, and appropriate responses to conditions in the organ are determined. Then, still other nerves send messages from the processing nerves back to the organ to control the function of the organ, for example, the contraction of the muscles of the organ. In the case of swallowing, processing of reflexes primarily occurs in nerves within the wall of the pharynx and esophagus as well as the brain.)
The complexity of swallowing also explains why there are so many causes of dysphagia. Problems can occur with:
The problems may lie within the pharynx or esophagus, for example, with the physical narrowing of the pharynx or esophagus. They also may be due to diseases of the muscles or the nerves that control the muscles of the pharynx and esophagus or damage to the swallowing center in the brain. Finally, the pharynx and the upper third of the esophagus contain muscle that is the same as the muscles that we use voluntarily (such as our arm muscles) called skeletal muscle. The lower two-thirds of the esophagus is composed of a different type of muscle known as smooth muscle. Thus, diseases that affect primarily skeletal muscle or smooth muscle in the body can affect the pharynx and esophagus, adding additional possibilities to the causes of dysphagia.
Odynophagia and globus sensationThere are two symptoms that are often thought of as problems with swallowing (dysphagia) that probably are not. These symptoms are odynophagia and globus sensation.
OdynophagiaOdynophagia means painful swallowing. Sometimes it is not easy for individuals to distinguish between odynophagia and dysphagia. For example, food that sticks in the esophagus often is painful. Is this dysphagia or odynophagia or both? Technically it is dysphagia, but individuals may describe it as painful swallowing (i.e., odynophagia). Moreover, patients with gastroesophageal reflux disease (GERD) may describe dysphagia when what they really have is odynophagia. The pain that they feel after swallowing resolves when the inflammation of GERD is treated and disappears and is presumably due to pain caused by food passing through the inflamed portion of the esophagus.
Odynophagia also may occur with other conditions associated with inflammation of the esophagus, for example, viral and fungal infections. It is important to distinguish between dysphagia and odynophagia because the causes of each may be quite different.
Globus sensationA globus sensation refers to a sensation that there is a lump in the throat. The lump may be present continuously or only when swallowing. The causes of a globus sensation are varied, and frequently no cause is found. Globus sensation has been attributed variously to abnormal function of the nerves or muscles of the pharynx and GERD. The globus sensation usually is described clearly by individuals and infrequently causes confusion with true dysphagia.
What causes dysphagia?
As discussed previously, there are many causes of dysphagia. For convenience, causes of dysphagia can be classified into two groups;
Causes also can be classified differently into several groups.
Physical obstruction of the pharynx or esophagus
Learn more about: K-Tab | Slow-K | Vibramycin | Oracea | Adoxa | Atridox | Quinidine Sulfate
Diseases of the brain
Diseases of the smooth muscle of the esophagus
Diseases of skeletal muscle of the pharynx
Miscellaneous diseases
Swallowing-related symptoms
With neurological problems, there may be difficulty initiating a swallow because the bolus cannot be propelled by the tongue into the throat. Elderly individuals with dentures may not chew their food well and therefore swallow large pieces of solid food that get stuck. (Nevertheless, this usually occurs when there is an additional problem within the pharynx or esophagus such as a stricture.)
The most common swallowing symptom of dysphagia, however, is the sensation that swallowed food is sticking, either in the lower neck or the chest. If food sticks in the throat, there may be coughing or choking with expectoration of the swallowed food. If food enters the larynx, more severe coughing and choking will be provoked. If the soft palate is not working and doesn't properly seal off the nasal passages, food—particularly liquids--can regurgitate into the nose with the swallow. Sometimes, food may come back up into the mouth immediately after being swallowed.
Non-swallowing-related
Food that sticks in the esophagus may remain there for prolonged periods of time. This may create a sensation of the chest filling up as more food is eaten and result in an individual having to stop eating and possibly drinking liquids in an attempt to wash the food down. The inability to eat larger amounts of food may lead to loss of weight. In addition, the food that remains in the esophagus may regurgitate from the esophagus at night while the individual is sleeping, and the individual might be awakened by coughing or choking in the middle of the night that is provoked by the regurgitating food. If food enters the larynx, trachea, and/or lungs, it may provoke episodes of asthma and even lead to infection of the lungs and pneumonia. Recurrent pneumonia can lead to serious, permanent, and progressive injury to the lungs. Occasionally, individuals are not awakened from sleep by the regurgitating food but awaken in the morning to find regurgitated food on their pillow.
Individuals who retain food in their esophagus may complain of heartburn-like (GERD) symptoms. Their symptoms may indeed be due to GERD but are more likely due to the retained food and do not respond well to treatment for GERD.
With the spastic motility disorders, individuals may develop episodes of chest pain that may be so severe as to mimic a heart attack and cause the individuals to go to the emergency room. The cause of the pain with the spastic esophageal disorders is unclear although the leading theory is that it is due to spasm of the esophageal muscles.
What is the differential diagnosis for dysphagia?
Odynophagia and globus sensation. The occasional difficulty in distinguishing dysphagia from odynophagia already has been discussed as well as the difference between dysphagia and a globus sensation.
Tracheo-esophageal fistula. One disorder that can be confused with dysphagia is tracheo-esophageal fistula. A tracheo-esophageal fistula is an open communication between the esophagus and the trachea that often develops due to cancers of the esophagus but which may also occur as a congenital (inborn) birth defect. Swallowed food may provoke coughing that mimics the coughing due to dysfunction of the muscles of the pharynx that allows food to enter the larynx; however, in the case of a fistula, the coughing is due to the passage of food from the esophagus through the fistula and into the trachea.
Rumination syndrome. Rumination syndrome is a syndrome in which food regurgitates effortlessly back into the mouth after a meal is completed. It usually occurs in younger women and conceivably could be confused with dysphagia. There is no sensation of food sticking after swallowing, however.
Gastroesophageal reflux disease (GERD). People with more severe GERD may have food regurgitate from the stomach into the esophagus or mouth, particularly when activities increase pressure in the abdomen, for example, with coughing and bending. Regurgitation also may occur at night while persons with GERD are sleeping as in those with swallowing disorders who have food collect in their esophagus.
Heart disease. The spastic motility disorders that cause dysphagia can be associated with spontaneous chest pain, that is, chest pain not associated with swallowing. Despite the presence of dysphagia, spontaneous chest pain always must be assumed to be due to heart disease until heart disease has been excluded as the cause of the chest pain. Therefore, it is important to test carefully for heart disease before considering the esophagus as the cause of chest pain when a patient with dysphagia complains of episodes of spontaneous chest pain.
How is dysphagia evaluated and the cause diagnosed?
HistoryThe history from an individual with dysphagia often provides important clues to the underlying cause of the dysphagia.
The nature of the symptom or symptoms provides the most important clues to the cause of dysphagia. Swallowing that is difficult to initiate or that leads to nasal regurgitation, cough, or choking is most likely due to an oral or pharyngeal problem. Swallowing that results in the sensation of food sticking in the chest (esophagus) is most likely due to an esophageal problem.
Dysphagia that progresses rapidly over weeks or a few months suggests a malignant tumor. Dysphagia for solid food alone suggests a physical obstruction to the passage of food, whereas dysphagia for both solid and liquid food is more likely to be caused by a disease of the smooth muscle of the esophagus. Intermittent symptoms also are more likely to be caused by diseases of smooth muscle than obstruction of the esophagus since dysfunction of the muscle often is intermittent.
Preexisting diseases also provide clues. Those with diseases of skeletal muscle (for example, polymyositis), the brain (most commonly stroke), or the nervous system are more likely to have dysphagia on the basis of dysfunction of the oropharyngeal muscles and nerves. People with collagen vascular diseases, for example, scleroderma, are more likely to have problems with the esophageal muscles, especially ineffective peristalsis.
Patients with a history of GERD are more likely to have esophageal strictures as the cause of their dysphagia, though about 20% of patients with strictures have minimal or no symptoms of GERD before the onset of dysphagia. It is believed that reflux that occurs at night is more injurious to the esophagus. There also is a higher risk of esophageal cancer among individuals with long-standing GERD.
Loss of weight can be a sign of either severe dysphagia or a malignant tumor. More often than losing weight, people describe a change in their eating pattern—smaller bites, additional chewing—that prolongs meals so that they are the last one at the table to finish eating. This latter pattern, if present for a prolonged period of time, suggests a non-malignant, relatively stable or slowly progressive cause for the dysphagia. Episodes of chest pain that are not due to heart disease suggest muscular diseases of the esophagus. Birth and residence in Central or South America is associated with Chagas disease.
Physical examinationThe physical examination is of limited value in suggesting causes for dysphagia. Abnormalities of the neurological examination suggest neurologic or muscle diseases. By observing an individual swallowing, one can determine if there is difficulty in initiating swallows, a sign of neurological disease. Tumors in the neck suggest the possibility of compression of the pharynx. A trachea that cannot be moved from side to side with the hand suggests a tumor lower down in the chest that has entrapped the trachea and possibly the esophagus. Observing atrophy (reduced size) or fasiculations of the tongue (fine tremors) also suggest diseases of the nervous system or skeletal muscle.
Endoscopy. Endoscopy involves the insertion of a long (one meter), flexible tube with a light and camera on its end through the mouth, pharynx, esophagus, and into the stomach. The lining of the pharynx and esophagus can be evaluated visually, and biopsies (small pieces of tissue) can be obtained for examination under the microscope or for bacterial or viral cultures.
Endoscopy is an excellent means of diagnosing tumors, strictures, and Schatzki's rings as well as infections of the esophagus. It also is very good for diagnosing diverticuli of the middle and lower esophagus but poor for diagnosing diverticuli in the upper esophagus (Zenker's diverticulum).
It is possible to observe abnormalities of esophageal muscular contraction, but esophageal manometry is a test that is much better suited for evaluating function of the esophageal muscles. Resistance passing the endoscope through the lower esophageal sphincter combined with a lack of esophageal contractions is a fairly reliable sign of achalasia or Chagas disease (due to the inability of the lower esophageal sphincter to relax), but it is important when there is resistance to exclude the presence of a stricture or cancer which also can cause resistance. Finally, there is a characteristic appearance of the esophageal lining when infiltrated with eosinophils that strongly suggests the presence of eosinophilic esophagitis.
X-rays. There are two different types of X-rays that can be done to diagnose the cause of dysphagia. The barium swallow or esophagram is the simplest type. For the barium swallow, mouthfuls of barium are swallowed, and X-ray films are taken of the esophagus at several points in time while the bolus of barium traverses the esophagus. The barium swallow is excellent for diagnosing moderate-to-severe external compression, tumors, and strictures of the esophagus. Occasionally, however, Schatzki's rings can be missed.
Another type of X-ray study that can be done to evaluate swallowing is the video esophagram or video swallow, sometimes called a video-fluoroscopic swallowing study. For the video swallow, instead of several static X-ray images of the bolus traversing the esophagus, a video X-ray is taken. The video study can be reviewed frame by frame and is able to show much more than the barium swallow. This usually is not important for diagnosing tumors or strictures, which are well seen on barium swallow, but it is more effective for suggesting problems with the contraction of the muscles of the esophagus and pharynx (though esophageal manometry, discussed later, is still better for studying contraction), milder external compression of the esophagus, and Schatzki's rings. The video study can be extended to include the pharynx where it is the best method for demonstrating osteophytes, cricopharyngeal bars, and Zenker's diverticuli. A modified barium swallow is a version of the test evaluating the oropharyngeal phases of swallowing. A speech pathologist is usually involved with the evaluation to determine subtle sequence and phase abnormalities.
The video swallow also is excellent for diagnosing penetration of barium (the equivalent of food) into the larynx and trachea due to neurological and muscular problems of the pharynx that may be causing coughing or choking after swallowing food.
Esophageal manometry. Esophageal manometry, also known as esophageal motility testing, is a means to evaluate the function of pharyngeal and esophageal muscles. For manometry, a thin, flexible catheter is passed through the nose and pharynx and into the esophagus. The catheter is able to sense pressure at multiple locations along its length in both the pharynx and the esophagus. When the pharyngeal and esophageal muscles contract, they generate a pressure on the catheter which is sensed, measured and recorded from each location. The magnitude of the pressure at each pressure-sensing location and the timing of the increases in pressure at each location in relation to other locations give an accurate picture of how the muscles of the pharynx and esophagus are functioning, that is, contracting.
The value of manometry is in diagnosing and differentiating among diseases of the muscle or the nerves controlling the muscles that result in muscle dysfunction of the pharynx and esophagus. Thus, it is useful for diagnosing the swallowing dysfunction caused by diseases of the brain, skeletal muscle of the pharynx, and smooth muscle of the esophagus.
Esophageal impedence. Esophageal impedence testing utilizes catheters similar to those used for esophageal manometry. Impedence testing, however, senses the flow of the bolus through the esophagus. Thus, it is possible to determine how well the bolus is traversing the esophagus and correlate the movement with concomitently recorded esophageal pressures determined by manometry. (It also can be used to sense reflux of stomach contents into the esophagus among patients with GERD.) Multiple sites along the length of the esophagus can be tested to assess the movement of the bolus and presence of reflux, including how high up it extends.
Esophageal acid testing. Esophageal acid testing is not a test that directly diagnoses diseases of the esophagus. Rather, it is a method for determining whether or not there is reflux of acid from the stomach and into the esophagus, a cause of the most common esophageal problem leading to dysphagia, esophageal stricture. For acid testing, a thin catheter is inserted through the nose, down the throat, and into the esophagus. At the tip of the catheter and placed just above the junction of the esophagus with the stomach is an acid-sensing probe. The catheter coming out of the nose passes back over the ear and down to the waist where it is attached to a recorder. Each time acid refluxes (regurgitates) from the stomach and into the esophagus it hits the probe, and the reflux of acid is recorded by the recorder. At the end of a prolonged period, usually 24 hours, the catheter is removed and the information from the recorder is downloaded into a computer for analysis. Most people have a small amount of reflux of acid, but individuals with GERD have more. Thus, acid testing can determine if GERD is likely to be the cause of the esophageal problem such as a stricture, as well as if treatment of GERD is adequate by showing that the amount of acid that refluxes during treatment is normal.
An alternative method of esophageal acid testing uses a small capsule containing an acid-sensing probe that is attached to the esophageal lining just above the junction of the esophagus with the stomach. The capsule wirelessly transmits the presence of episodes of acid regurgitation to a receiver carried on the chest. The capsule records for two or three days and later is shed into the esophagus and passes out of the body in the stool.
Other tests.The diagnosis of muscular dystrophies and metabolic myopathies usually involves a combination of tests including blood tests that can suggest muscle injury, electromyograms to determine if nerves and muscles are working normally, biopsies of muscles, and genetic testing.
How is dysphagia treated?
The treatment of dysphagia varies and depends on the cause of the dysphagia. One option for supporting patients either transiently or long-term until the cause of the dysphagia resolves is a feeding tube. The tube for feeding may be passed nasally into the stomach or through the abdominal wall into the stomach or small intestine. Once oral feeding resumes, the tube can be removed.
Physical obstruction of the pharynx or esophagusTreatment for obstruction of the pharynx or esophagus requires removal of the obstruction.
Tumors usually are removed surgically although occasionally they can be removed endoscopically, totally or partially. Radiation therapy and chemotherapy also may be used particularly for malignant tumors of the pharynx and its surrounding tissues. If malignant tumors of the esophagus cannot be easily removed or the tumor has spread and survival will be limited, swallowing can be improved by placing stents within the esophagus across the area of obstruction. Occasionally, obstructing tumors can be dilated the same way as strictures. (See below.)
Strictures and Schatzki's rings usually are treated with endoscopic dilation, a procedure in which the narrowed area is stretched either by a long, semi-rigid tube passed through the mouth or a balloon that is blown up inside the esophagus.
The most common infiltrating disease causing dysphagia is eosinophilic esophagitis which usually is successfully treated with swallowed corticosteroids. The role of food allergy as a cause of eosinophilic esophagitis is debated; however, there are reports of using elimination diets to identify specific foods that are associated with allergy. Elimination of these foods has been reported to prevent or reverse the infiltration of the esophagus with eosinophils, particularly in children.
Diverticuli of the pharynx and esophagus usually are treated surgically by excising them or by opening them up widely to the esophagus so that food does not collect in them. Occasionally they can be treated endoscopically. Cricopharyngeal bars are treated surgically by cutting the thickened muscle. Osteophytes also can be removed surgically.
Congenital abnormalities of the esophagus usually are treated surgically soon after birth so that oral feeding can resume.
Diseases of the brainAs previously discussed, strokes are the most common disease of the brain to cause dysphagia. Dysphagia usually is at its worst immediately after the stroke, and often the dysphagia improves with time and even may disappear. If it does not disappear, swallowing is evaluated, usually with a video swallowing study. The exact abnormality of function can be defined and different maneuvers can be tested to see if they can counter the effects of the dysfunction. For example, in some patients it is possible to prevent aspiration of food by turning the head to the side when swallowing or by drinking thickened liquids (since thin liquids is the food most likely to be aspirated).
Tumors of the brain, in some cases, can be removed surgically; however, it is unlikely that surgery will reverse the dysphagia. Parkinson's disease and multiple sclerosis can be treated with drugs and may be useful in patients with dysphagia.
Diseases of smooth muscle of the esophagusAchalasia is treated like a stricture of the esophagus with dilation, usually with a balloon. A second option is surgical treatment in which the muscle of the lower esophageal sphincter is cut (a myotomy) in order to reduce the pressure and obstruction caused by the non-relaxing sphincter. Drugs that relax the sphincter usually have little or a transient effect and are useful only when achalasia is mild.
An option for individuals who are at high risk for surgery or balloon dilation is injection of botulinin toxin into the sphincter. The toxin damages the muscle of the sphincter and causes the pressure within the sphincter to decrease. The effects of botulinin toxin are transient, however, and repeated injections usually are necessary. It is best to treat achalasia early before the obstruction causes the esophagus to enlarge (dilate) which can lead to additional problems such as food collecting above the sphincter with regurgitation and aspiration.
In other spastic motility disorders, several drugs may be tried, including anti-cholinergic medications, peppermint, nitroglycerin, and calcium channel blockers, but the effectiveness of these drugs is not clear and studies with them are nonexistent or limited.
For patients with severe and uncontrollable symptoms of pain and/or dysphagia, a surgical procedure called a long myotomy occasionally is performed. A long myotomy is similar to the surgical treatment for achalasia but the cut in the muscle is extended up along the body of the esophagus for a variable distance in an attempt to reduce pressures and obstruction to the bolus.
There is no treatment for ineffective peristalsis, and individuals must change their eating habits. Fortunately, ineffective peristalsis infrequently causes severe dysphagia by itself. When moderate or severe dysphagia is associated with ineffective peristalsis it is important to be certain that there is no additional obstruction of the esophagus, for example, by a stricture due to GERD, that is adding to the effects of reduced muscle function and making dysphagia worse than the ineffective peristalsis alone. Most causes of obstruction can be treated.
Diseases of the skeletal muscle of the pharynxThere are effective drug therapies for polymyositis and myasthenia gravis that should also improve associated dysphagia. Treatment of the muscular dystrophies is primarily directed at preventing deformities of the joints that commonly occur and lead to immobility, but there are no therapies that affect the dysphagia. Corticosteroids and drugs that suppress immunity sometimes are used to treat some of the muscular dystrophies, but their effectiveness has not been demonstrated.
There is no treatment for the metabolic myopathies other than changes in lifestyle and diet.
Miscellaneous diseasesDiseases that reduce the production of saliva can be treated with artificial saliva or over-the-counter and prescription drugs that stimulate the production of saliva.
There is no treatment for Alzheimer's disease.
What causes dysphagia?
As discussed previously, there are many causes of dysphagia. For convenience, causes of dysphagia can be classified into two groups;
Causes also can be classified differently into several groups.
Physical obstruction of the pharynx or esophagus
Learn more about: K-Tab | Slow-K | Vibramycin | Oracea | Adoxa | Atridox | Quinidine Sulfate
Diseases of the brain
Diseases of the smooth muscle of the esophagus
Diseases of skeletal muscle of the pharynx
Miscellaneous diseases
Swallowing-related symptoms
With neurological problems, there may be difficulty initiating a swallow because the bolus cannot be propelled by the tongue into the throat. Elderly individuals with dentures may not chew their food well and therefore swallow large pieces of solid food that get stuck. (Nevertheless, this usually occurs when there is an additional problem within the pharynx or esophagus such as a stricture.)
The most common swallowing symptom of dysphagia, however, is the sensation that swallowed food is sticking, either in the lower neck or the chest. If food sticks in the throat, there may be coughing or choking with expectoration of the swallowed food. If food enters the larynx, more severe coughing and choking will be provoked. If the soft palate is not working and doesn't properly seal off the nasal passages, food—particularly liquids--can regurgitate into the nose with the swallow. Sometimes, food may come back up into the mouth immediately after being swallowed.
Non-swallowing-related
Food that sticks in the esophagus may remain there for prolonged periods of time. This may create a sensation of the chest filling up as more food is eaten and result in an individual having to stop eating and possibly drinking liquids in an attempt to wash the food down. The inability to eat larger amounts of food may lead to loss of weight. In addition, the food that remains in the esophagus may regurgitate from the esophagus at night while the individual is sleeping, and the individual might be awakened by coughing or choking in the middle of the night that is provoked by the regurgitating food. If food enters the larynx, trachea, and/or lungs, it may provoke episodes of asthma and even lead to infection of the lungs and pneumonia. Recurrent pneumonia can lead to serious, permanent, and progressive injury to the lungs. Occasionally, individuals are not awakened from sleep by the regurgitating food but awaken in the morning to find regurgitated food on their pillow.
Individuals who retain food in their esophagus may complain of heartburn-like (GERD) symptoms. Their symptoms may indeed be due to GERD but are more likely due to the retained food and do not respond well to treatment for GERD.
With the spastic motility disorders, individuals may develop episodes of chest pain that may be so severe as to mimic a heart attack and cause the individuals to go to the emergency room. The cause of the pain with the spastic esophageal disorders is unclear although the leading theory is that it is due to spasm of the esophageal muscles.
What is the differential diagnosis for dysphagia?
Odynophagia and globus sensation. The occasional difficulty in distinguishing dysphagia from odynophagia already has been discussed as well as the difference between dysphagia and a globus sensation.
Tracheo-esophageal fistula. One disorder that can be confused with dysphagia is tracheo-esophageal fistula. A tracheo-esophageal fistula is an open communication between the esophagus and the trachea that often develops due to cancers of the esophagus but which may also occur as a congenital (inborn) birth defect. Swallowed food may provoke coughing that mimics the coughing due to dysfunction of the muscles of the pharynx that allows food to enter the larynx; however, in the case of a fistula, the coughing is due to the passage of food from the esophagus through the fistula and into the trachea.
Rumination syndrome. Rumination syndrome is a syndrome in which food regurgitates effortlessly back into the mouth after a meal is completed. It usually occurs in younger women and conceivably could be confused with dysphagia. There is no sensation of food sticking after swallowing, however.
Gastroesophageal reflux disease (GERD). People with more severe GERD may have food regurgitate from the stomach into the esophagus or mouth, particularly when activities increase pressure in the abdomen, for example, with coughing and bending. Regurgitation also may occur at night while persons with GERD are sleeping as in those with swallowing disorders who have food collect in their esophagus.
Heart disease. The spastic motility disorders that cause dysphagia can be associated with spontaneous chest pain, that is, chest pain not associated with swallowing. Despite the presence of dysphagia, spontaneous chest pain always must be assumed to be due to heart disease until heart disease has been excluded as the cause of the chest pain. Therefore, it is important to test carefully for heart disease before considering the esophagus as the cause of chest pain when a patient with dysphagia complains of episodes of spontaneous chest pain.
How is dysphagia evaluated and the cause diagnosed?
HistoryThe history from an individual with dysphagia often provides important clues to the underlying cause of the dysphagia.
The nature of the symptom or symptoms provides the most important clues to the cause of dysphagia. Swallowing that is difficult to initiate or that leads to nasal regurgitation, cough, or choking is most likely due to an oral or pharyngeal problem. Swallowing that results in the sensation of food sticking in the chest (esophagus) is most likely due to an esophageal problem.
Dysphagia that progresses rapidly over weeks or a few months suggests a malignant tumor. Dysphagia for solid food alone suggests a physical obstruction to the passage of food, whereas dysphagia for both solid and liquid food is more likely to be caused by a disease of the smooth muscle of the esophagus. Intermittent symptoms also are more likely to be caused by diseases of smooth muscle than obstruction of the esophagus since dysfunction of the muscle often is intermittent.
Preexisting diseases also provide clues. Those with diseases of skeletal muscle (for example, polymyositis), the brain (most commonly stroke), or the nervous system are more likely to have dysphagia on the basis of dysfunction of the oropharyngeal muscles and nerves. People with collagen vascular diseases, for example, scleroderma, are more likely to have problems with the esophageal muscles, especially ineffective peristalsis.
Patients with a history of GERD are more likely to have esophageal strictures as the cause of their dysphagia, though about 20% of patients with strictures have minimal or no symptoms of GERD before the onset of dysphagia. It is believed that reflux that occurs at night is more injurious to the esophagus. There also is a higher risk of esophageal cancer among individuals with long-standing GERD.
Loss of weight can be a sign of either severe dysphagia or a malignant tumor. More often than losing weight, people describe a change in their eating pattern—smaller bites, additional chewing—that prolongs meals so that they are the last one at the table to finish eating. This latter pattern, if present for a prolonged period of time, suggests a non-malignant, relatively stable or slowly progressive cause for the dysphagia. Episodes of chest pain that are not due to heart disease suggest muscular diseases of the esophagus. Birth and residence in Central or South America is associated with Chagas disease.
Physical examinationThe physical examination is of limited value in suggesting causes for dysphagia. Abnormalities of the neurological examination suggest neurologic or muscle diseases. By observing an individual swallowing, one can determine if there is difficulty in initiating swallows, a sign of neurological disease. Tumors in the neck suggest the possibility of compression of the pharynx. A trachea that cannot be moved from side to side with the hand suggests a tumor lower down in the chest that has entrapped the trachea and possibly the esophagus. Observing atrophy (reduced size) or fasiculations of the tongue (fine tremors) also suggest diseases of the nervous system or skeletal muscle.
Endoscopy. Endoscopy involves the insertion of a long (one meter), flexible tube with a light and camera on its end through the mouth, pharynx, esophagus, and into the stomach. The lining of the pharynx and esophagus can be evaluated visually, and biopsies (small pieces of tissue) can be obtained for examination under the microscope or for bacterial or viral cultures.
Endoscopy is an excellent means of diagnosing tumors, strictures, and Schatzki's rings as well as infections of the esophagus. It also is very good for diagnosing diverticuli of the middle and lower esophagus but poor for diagnosing diverticuli in the upper esophagus (Zenker's diverticulum).
It is possible to observe abnormalities of esophageal muscular contraction, but esophageal manometry is a test that is much better suited for evaluating function of the esophageal muscles. Resistance passing the endoscope through the lower esophageal sphincter combined with a lack of esophageal contractions is a fairly reliable sign of achalasia or Chagas disease (due to the inability of the lower esophageal sphincter to relax), but it is important when there is resistance to exclude the presence of a stricture or cancer which also can cause resistance. Finally, there is a characteristic appearance of the esophageal lining when infiltrated with eosinophils that strongly suggests the presence of eosinophilic esophagitis.
X-rays. There are two different types of X-rays that can be done to diagnose the cause of dysphagia. The barium swallow or esophagram is the simplest type. For the barium swallow, mouthfuls of barium are swallowed, and X-ray films are taken of the esophagus at several points in time while the bolus of barium traverses the esophagus. The barium swallow is excellent for diagnosing moderate-to-severe external compression, tumors, and strictures of the esophagus. Occasionally, however, Schatzki's rings can be missed.
Another type of X-ray study that can be done to evaluate swallowing is the video esophagram or video swallow, sometimes called a video-fluoroscopic swallowing study. For the video swallow, instead of several static X-ray images of the bolus traversing the esophagus, a video X-ray is taken. The video study can be reviewed frame by frame and is able to show much more than the barium swallow. This usually is not important for diagnosing tumors or strictures, which are well seen on barium swallow, but it is more effective for suggesting problems with the contraction of the muscles of the esophagus and pharynx (though esophageal manometry, discussed later, is still better for studying contraction), milder external compression of the esophagus, and Schatzki's rings. The video study can be extended to include the pharynx where it is the best method for demonstrating osteophytes, cricopharyngeal bars, and Zenker's diverticuli. A modified barium swallow is a version of the test evaluating the oropharyngeal phases of swallowing. A speech pathologist is usually involved with the evaluation to determine subtle sequence and phase abnormalities.
The video swallow also is excellent for diagnosing penetration of barium (the equivalent of food) into the larynx and trachea due to neurological and muscular problems of the pharynx that may be causing coughing or choking after swallowing food.
Esophageal manometry. Esophageal manometry, also known as esophageal motility testing, is a means to evaluate the function of pharyngeal and esophageal muscles. For manometry, a thin, flexible catheter is passed through the nose and pharynx and into the esophagus. The catheter is able to sense pressure at multiple locations along its length in both the pharynx and the esophagus. When the pharyngeal and esophageal muscles contract, they generate a pressure on the catheter which is sensed, measured and recorded from each location. The magnitude of the pressure at each pressure-sensing location and the timing of the increases in pressure at each location in relation to other locations give an accurate picture of how the muscles of the pharynx and esophagus are functioning, that is, contracting.
The value of manometry is in diagnosing and differentiating among diseases of the muscle or the nerves controlling the muscles that result in muscle dysfunction of the pharynx and esophagus. Thus, it is useful for diagnosing the swallowing dysfunction caused by diseases of the brain, skeletal muscle of the pharynx, and smooth muscle of the esophagus.
Esophageal impedence. Esophageal impedence testing utilizes catheters similar to those used for esophageal manometry. Impedence testing, however, senses the flow of the bolus through the esophagus. Thus, it is possible to determine how well the bolus is traversing the esophagus and correlate the movement with concomitently recorded esophageal pressures determined by manometry. (It also can be used to sense reflux of stomach contents into the esophagus among patients with GERD.) Multiple sites along the length of the esophagus can be tested to assess the movement of the bolus and presence of reflux, including how high up it extends.
Esophageal acid testing. Esophageal acid testing is not a test that directly diagnoses diseases of the esophagus. Rather, it is a method for determining whether or not there is reflux of acid from the stomach and into the esophagus, a cause of the most common esophageal problem leading to dysphagia, esophageal stricture. For acid testing, a thin catheter is inserted through the nose, down the throat, and into the esophagus. At the tip of the catheter and placed just above the junction of the esophagus with the stomach is an acid-sensing probe. The catheter coming out of the nose passes back over the ear and down to the waist where it is attached to a recorder. Each time acid refluxes (regurgitates) from the stomach and into the esophagus it hits the probe, and the reflux of acid is recorded by the recorder. At the end of a prolonged period, usually 24 hours, the catheter is removed and the information from the recorder is downloaded into a computer for analysis. Most people have a small amount of reflux of acid, but individuals with GERD have more. Thus, acid testing can determine if GERD is likely to be the cause of the esophageal problem such as a stricture, as well as if treatment of GERD is adequate by showing that the amount of acid that refluxes during treatment is normal.
An alternative method of esophageal acid testing uses a small capsule containing an acid-sensing probe that is attached to the esophageal lining just above the junction of the esophagus with the stomach. The capsule wirelessly transmits the presence of episodes of acid regurgitation to a receiver carried on the chest. The capsule records for two or three days and later is shed into the esophagus and passes out of the body in the stool.
Other tests.The diagnosis of muscular dystrophies and metabolic myopathies usually involves a combination of tests including blood tests that can suggest muscle injury, electromyograms to determine if nerves and muscles are working normally, biopsies of muscles, and genetic testing.
How is dysphagia treated?
The treatment of dysphagia varies and depends on the cause of the dysphagia. One option for supporting patients either transiently or long-term until the cause of the dysphagia resolves is a feeding tube. The tube for feeding may be passed nasally into the stomach or through the abdominal wall into the stomach or small intestine. Once oral feeding resumes, the tube can be removed.
Physical obstruction of the pharynx or esophagusTreatment for obstruction of the pharynx or esophagus requires removal of the obstruction.
Tumors usually are removed surgically although occasionally they can be removed endoscopically, totally or partially. Radiation therapy and chemotherapy also may be used particularly for malignant tumors of the pharynx and its surrounding tissues. If malignant tumors of the esophagus cannot be easily removed or the tumor has spread and survival will be limited, swallowing can be improved by placing stents within the esophagus across the area of obstruction. Occasionally, obstructing tumors can be dilated the same way as strictures. (See below.)
Strictures and Schatzki's rings usually are treated with endoscopic dilation, a procedure in which the narrowed area is stretched either by a long, semi-rigid tube passed through the mouth or a balloon that is blown up inside the esophagus.
The most common infiltrating disease causing dysphagia is eosinophilic esophagitis which usually is successfully treated with swallowed corticosteroids. The role of food allergy as a cause of eosinophilic esophagitis is debated; however, there are reports of using elimination diets to identify specific foods that are associated with allergy. Elimination of these foods has been reported to prevent or reverse the infiltration of the esophagus with eosinophils, particularly in children.
Diverticuli of the pharynx and esophagus usually are treated surgically by excising them or by opening them up widely to the esophagus so that food does not collect in them. Occasionally they can be treated endoscopically. Cricopharyngeal bars are treated surgically by cutting the thickened muscle. Osteophytes also can be removed surgically.
Congenital abnormalities of the esophagus usually are treated surgically soon after birth so that oral feeding can resume.
Diseases of the brainAs previously discussed, strokes are the most common disease of the brain to cause dysphagia. Dysphagia usually is at its worst immediately after the stroke, and often the dysphagia improves with time and even may disappear. If it does not disappear, swallowing is evaluated, usually with a video swallowing study. The exact abnormality of function can be defined and different maneuvers ca
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Causes also can be classified differently into several groups.
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