Alpha thalassemia
This type occurs when one or more of the four alpha-globin genes that make hemoglobin are missing or damaged.
- If one gene is missing or damaged: Your red blood cells might be smaller than normal. You will have no symptoms and you will not need treatment. But you are a silent carrier. This means you don't have the disease but can pass the defective gene to your child.
- If two genes are missing or damaged: You will have very mild anemia that will typically not need treatment. This is called alpha thalassemia minor or alpha thalassemia trait.
- If three genes are missing: You will have mild to moderately severe anemia. This is sometimes called hemoglobin H disease. If it is severe, you may need blood transfusions.
- If all four genes are missing: This is called alpha thalassemia major or hydrops fetalis. The fetus will be stillborn, or the child will die soon after birth.
Source: http://www.webmd.com