Drug: Zaltrap (aflibercept)

What is aflibercept (Zaltrap)? Aflibercept is made from a human antibody fragment. It works by keeping new blood vessels from forming in a fast-growing tumor.Aflibercept is used in combination with other medications to treat colorectal cancer.Aflibercept is usually given after other cancer medications have been tried without successful treatment.Aflibercept may also be used for purposes not listed in this medication guide.

Source: http://www.emedicinehealth.com

What are the possible side effects of aflibercept (Zaltrap)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.Call your doctor at once if you have a serious side effect such as:
  • feeling light-headed or short of breath, trouble concentrating;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • any bleeding that will not stop;
  • any wound that will not heal;
  • severe or ongoing vomiting or diarrhea;
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, change in mental status, problems with speech or balance, vision loss, seizure (convulsions);
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • pain or burning when you urinate;
  • rectal pain, foul-smelling vaginal discharge, pain or swelling in your lower stomach, problems with urination or bowel movements;
  • puffy eyes, swelling in your ankles or feet, weight gain, urine that looks foamy; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
  • stomach pain, mild diarrhea;
  • loss of appetite, weight loss;
  • mild headache;
  • feeling tired; or
  • hoarse voice.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: http://www.emedicinehealth.com

What other drugs will affect aflibercept (Zaltrap)? There may be other drugs that can interact with aflibercept. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Source: http://www.emedicinehealth.com

What happens if I overdose (Zaltrap)? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Source: http://www.emedicinehealth.com

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