Drug: Amevive (alefacept)

What is alefacept (Amevive)? Alefacept is a protein that reduces specific actions of the immune system that are involved in causing psoriasis.Alefacept is used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults.Alefacept may also be used for purposes not listed in this medication guide.

Source: http://www.emedicinehealth.com

What are the possible side effects of alefacept (Amevive)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.Stop using alefacept and call your doctor at once if you have a serious side effect such as:
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • cough with yellow or green mucus, stabbing chest pain, wheezing, feeling short of breath;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • swelling, warmth, redness, itching, or oozing from the skin;
  • new skin lesions, or a sunburn-like skin rash; or
  • worsening or no improvement of your skin condition.
Less serious side effects may include:
  • sore throat, cough;
  • dizziness;
  • mild nausea;
  • headache;
  • itching;
  • muscle pain;
  • pain or swelling where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: http://www.emedicinehealth.com

What other drugs will affect alefacept (Amevive)? Tell your doctor about all other medicines you use, especially:
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • digoxin (digitalis, Lanoxin, Lanoxicaps);
  • fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis);
  • levothyroxine (Synthroid, Levothroid);
  • lithium (Eskalith, Lithobid);
  • pimozide (Orap);
  • sirolimus (Rapamune) or tacrolimus (Prograf);
  • theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
  • ergot medicine such as ergotamine (Ergomar, Cafergot) or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), divalproex (Depakote), ethosuximide (Zarontin), phenytoin (Dilantin), or valproic acid (Depakene, Stavzor); or
  • heart rhythm medication such as disopyramide (Norpace), procainamide (Procan, Pronestyl), or quinidine (Quin-G).
This list is not complete and other drugs may interact with alefacept. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Source: http://www.emedicinehealth.com

What happens if I overdose (Amevive)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

Source: http://www.emedicinehealth.com

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