Drug: AmBisome (amphotericin B liposomal)

What is amphotericin B liposomal (AmBisome)? Amphotericin B liposomal is an antifungal antibiotic that fights infections caused by fungus.Amphotericin B liposomal is used to treat serious, life-threatening fungal infections including leishmaniasis, and a certain form of meningitis in people infected with HIV (human immunodeficiency virus). Amphotericin B liposomal is not for treating a minor fungal infection such as a yeast infection of the mouth, esophagus, or vagina.Amphotericin B liposomal may also be used for purposes not listed in this medication guide.

Source: http://www.emedicinehealth.com

What are the possible side effects of amphotericin B liposomal (AmBisome)? Some people receiving a amphotericin B liposomal injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, hot or cold, or if you have a fast heartbeat, chest tightness, or trouble breathing.Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.Call your doctor at once if you have a serious side effect such as:
  • chest pain, pounding heartbeats or fluttering in your chest;
  • feeling light-headed or short of breath;
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, limp feeling);
  • loss of appetite, vomiting, urinating less than usual or not at all;
  • swelling, rapid weight gain;
  • pale skin, weakness, rapid heart rate, trouble concentrating; or
  • muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine).
Less serious side effects may include:
  • chills;
  • nausea, diarrhea;
  • stomach pain;
  • headache;
  • flushing (warmth, redness, or tingly feeling);
  • sleep problems (insomnia); or
  • mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: http://www.emedicinehealth.com

What other drugs will affect amphotericin B liposomal (AmBisome)? Amphotericin B liposomal can harm your kidneys. This effect is increased when you also use other medicines harmful to the kidneys. You may need dose adjustments or special tests if you have recently used:
  • medicines to treat a bowel disorder;
  • medication to prevent organ transplant rejection;
  • antiviral medications;
  • chemotherapy;
  • pain or arthritis medicines; or
  • any other injected antibiotics.
Tell your doctor about all other medicines you use, especially:
  • digoxin (digitalis, Lanoxin, Lanoxicaps);
  • flucytosine (Ancobon);
  • antifungal medication such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
  • any cancer medications; or
  • steroid medication (prednisone and others).
This list is not complete and other drugs may interact with amphotericin B liposomal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Source: http://www.emedicinehealth.com

What happens if I overdose (AmBisome)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Source: http://www.emedicinehealth.com

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