Drug: Agrylin (anagrelide)

What is anagrelide (Agrylin)? Anagrelide lowers the number of blood clotting cells (platelets) in the body, which helps prevent blood clots from forming.Anagrelide is used to treat a condition called thrombocythemia (also called thrombocytosis). Thrombocythemia is a blood cell disorder in which too many platelet cells are produced, causing bleeding or blood-clotting problems.Anagrelide may also be used for purposes not listed in this medication guide. Anagrelide 0.5 mg-BARcapsule, white, imprinted with barr 0.5 mg, 101Anagrelide 0.5 mg-IVAcapsule, gray/white, imprinted with LOGO 5241, 0.5 mgAnagrelide 0.5 mg-MYLcapsule, gray/orange, imprinted with MYLAN 6868Anagrelide 1 mg-BARcapsule, gray, imprinted with barr 1 mg, 102Anagrelide 1 mg-IVAcapsule, white, imprinted with LOGO 5240, 1 mgAnagrelide 1 mg-MYLcapsule, blue/gray, imprinted with MYLAN 6869 featuredcontentslider.init({ id: "slider1", contentsource: ["inline", ""], toc: "#increment", nextprev: ["Prev", "Next"], revealtype: "click", enablefade: [true, 0.2], autorotate: [true, 100000], onChange: function(previndex, curindex){ } })

Source: http://www.emedicinehealth.com

What are the possible side effects of anagrelide (Agrylin)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Call your doctor at once if you have a serious side effect such as:
  • sudden chest pain or discomfort, rapid breathing, wheezing, dry cough or hack;
  • swelling, rapid weight gain, feeling short of breath (even with mild exertion);
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • sudden cough, wheezing, rapid breathing, coughing up blood;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • pounding heartbeats or fluttering in your chest;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • fever, chills, body aches, flu symptoms; or
  • blood in your urine, painful or difficult urination.
Less serious side effects may include:
  • dizziness, mild headache;
  • nausea, vomiting, loss of appetite;
  • diarrhea, constipation, stomach pain, gas, upset stomach;
  • mild rash or itching;
  • runny or stuffy nose, sore throat;
  • numbness or tingly feeling
  • back pain; or
  • vision problems, ringing in your ears.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: http://www.emedicinehealth.com

What other drugs will affect anagrelide (Agrylin)? Tell your doctor about all other medicines you use, especially:
  • dasatinib (Sprycel);
  • deferasirox (Exjade);
  • fluvoxamine (Luvox);
  • theophylline (Elixophyllin, Theo-24, Uniphyl);
  • tipranavir (Aptivus);
  • tizanidine (Zanaflex);
  • drugs to treat non-Hodgkin's lymphoma, such as ibritumomab (Zevalin), or iodine I-131 tositumomab (Bexxar);
  • medication to treat congestive heart failure, such as amrinone (inamrinone, Inocor), enoximone (Perfan), or milrinone (Primacor);
  • medicines to treat or prevent blood clots, such as dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), or tinzaparin (Innohep); or
  • other anti-platelet drugs such as abciximab (ReoPro), cilostazol (Pletal), danaparoid (Orgaran), eptifibatide (Integrelin), prasugrel (Effient), rivaroxaban (Xarelto), or tirofiban (Aggrastat).
This list is not complete and other drugs may interact with anagrelide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Source: http://www.emedicinehealth.com

What happens if I overdose (Agrylin)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose can cause vomiting, or fast heart rate.

Source: http://www.emedicinehealth.com

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