Drug: Alka-Seltzer Plus Cold Formula (aspirin, chlorpheniramine, and phenylephrine)

What is aspirin, chlorpheniramine, and phenylephrine (Alka-Seltzer Plus Cold Formula)? Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).The combination of aspirin, chlorpheniramine, and phenylephrine is used to treat fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.Aspirin, chlorpheniramine, and phenylephrine may also be used for purposes not listed in this medication guide.

Source: http://www.emedicinehealth.com

What are the possible side effects of this medicine (Alka-Seltzer Plus Cold Formula)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Stop using this medicine and call your doctor at once if you have a serious side effect such as:
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • fast, slow, or uneven heart rate, tremor, seizure (convulsions);
  • ringing in your ears, severe headache, mood changes, severe dizziness or anxiety, hallucinations, feeling like you might pass out;
  • redness or swelling, new cold or flu symptoms;
  • feeling short of breath, urinating less than usual or not at all; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, uneven heartbeats, seizure).
Less serious side effects may include:
  • mild headache, mild dizziness, drowsiness;
  • dry mouth, nose, or throat;
  • heartburn, nausea, diarrhea, constipation, upset stomach;
  • feeling nervous, restless, or irritable; or
  • sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: http://www.emedicinehealth.com

What other drugs will affect aspirin, chlorpheniramine, and phenylephrine (Alka-Seltzer Plus Cold Formula)? Ask your doctor before using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), trazodone (Desyrel, Oleptro), or vilazodone (Viibryd). Taking any of these medicines with aspirin may cause you to bruise or bleed easily.Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.Ask a doctor or pharmacist if it is safe for you to use aspirin, chlorpheniramine, and phenylephrine if you are also using any of the following drugs:
  • topiramate (Topamax);
  • zonisamide (Zonegran);
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • gout medication such as probenecid (Benemid);
  • phenobarbital (Solfoton) or other barbiturates;
  • anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);
  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;
  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
  • irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);
  • a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or
  • ulcer medicine such as glycopyrrolate (Robinul) or mepenzolate (Cantil).
This list is not complete and other drugs may interact with aspirin, chlorpheniramine, and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Source: http://www.emedicinehealth.com

What happens if I overdose (Alka-Seltzer Plus Cold Formula)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

Source: http://www.emedicinehealth.com

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