Drug: DuoDote (atropine and pralidoxime)

What is atropine and pralidoxime (DuoDote)? Atropine blocks the action of chemical called acetylcholine (ah see til KO leen), which may exist in high levels in the body after a poisoning. Atropine also stimulates the heart and reduces the secretions of the nose, mouth, and lungs to improve breathing.Pralidoxime reverses muscle weakness or paralysis caused by a poison or nerve agent.The combination of atropine and pralidoxime is used as an antidote to treat poisoning by a pesticide (insect spray) or a chemical that interferes with the central nervous system, such as nerve gas.This medication is not effective as an antidote for all types of pesticide poisonings. You may need medications or additional treatments.Atropine and pralidoxime may also be used for purposes not listed in this medication guide.

Source: http://www.emedicinehealth.com

What are the possible side effects of atropine and pralidoxime (DuoDote)? Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Tell your caregivers at once if you have a serious side effect such as:
  • pounding heartbeats or fluttering in your chest;
  • painful or difficult urination;
  • trouble swallowing;
  • feeling like you might pass out;
  • confusion;
  • loss of movement in any part of your body;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); or
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
Less serious side effects may include:
  • dry mouth, dry nose, dry skin;
  • dry eyes, blurred vision;
  • increased sensitivity of your eyes to light;
  • headache;
  • dizziness, drowsiness;
  • muscle weakness;
  • constipation, stomach pain, bloating, nausea, vomiting;
  • loss of interest in sex, impotence; or
  • mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: http://www.emedicinehealth.com

What other drugs will affect atropine and pralidoxime (DuoDote)? If possible, before you receive this medication, tell your doctor about all other medicines you use, especially:
  • aminophylline (Phyllocontin, Truphylline);
  • morphine (Avinza, Kadian, MS Contin, Oramorph);
  • reserpine;
  • theophylline (Elixophyllin, Theo-24, Uniphyl);
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or
  • a tranquilizer such as chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).
This list is not complete and other drugs may interact with atropine and pralidoxime. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Source: http://www.emedicinehealth.com

What happens if I overdose (DuoDote)? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.Overdose may occur if you receive atropine and pralidoxime but you have not actually been exposed to the specific poisons this medication is designed to treat. Symptoms may include vision problems, feeling unsteady, loss of balance or coordination, trouble concentrating, fast heart rate, confusion, hallucinations (seeing or hearing things), decreased sweating, hot and dry skin, fainting, weak or shallow breathing, or breathing that stops.

Source: http://www.emedicinehealth.com

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