Drug: Inlyta (axitinib)

What is axitinib (Inlyta)? Axitinib is a cancer medication that interferes with the growth and spread of cancer cells in the body.Axitinib is used to treat cancer of the kidney.Axitinib is usually given after other cancer medication has been tried without successful treatment.Axitinib may also be used for purposes not listed in this medication guide.

Source: http://www.emedicinehealth.com

What are the possible side effects of axitinib (Inlyta)? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.Stop using axitinib and call your doctor at once if you have a serious side effect such as:
  • sudden numbness or weakness, problems with speech or balance;
  • pain, swelling, warmth, or redness in one or both legs;
  • severe headache, confusion, change in mental status, vision loss, and/or seizure (convulsions);
  • severe stomach pain;
  • red or pink urine, bloody or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;
  • any wound that will not heal;
  • sudden weight loss, increased appetite, pounding heartbeats, fluttering in your chest, feeling very weak or tired, muscle pain, numbness or tingling in your hands, dry skin and hair, feeling hot or cold, changes in your menstrual periods, hoarse voice, swelling in your neck or throat (enlarged thyroid); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats).
Less serious side effects may include:
  • nausea, vomiting;
  • diarrhea, constipation; or
  • loss of appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: http://www.emedicinehealth.com

What other drugs will affect axitinib (Inlyta)? Tell your doctor about all other medicines you use, especially:
  • boceprevir (Victrelis);
  • bosentan (Tracleer);
  • conivaptan (Vaprisol);
  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • nefazodone;
  • St. John's wort;
  • theophylline (Elixophyllin, Theochron, Uniphyl);
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);
  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
  • heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);
  • HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), saquinavir (Invirase), or telaprevir (Incivek);
  • medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); or
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).
There may be other drugs that can interact with axitinib. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Source: http://www.emedicinehealth.com

What happens if I overdose (Inlyta)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include seizure (convulsions).

Source: http://www.emedicinehealth.com

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