Tramadol/acetaminophen is a prescription controlled substance. Itâs available as an oral tablet. Tramadol/acetaminophen is a combination of two or more drugs in a single form. Itâs important to know about all the drugs in the combination because they each may have unique traits. Tramadol/acetaminophen is available in its generic form. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.