Drug: aldesleukin

Aldesleukin causes side effects in almost every organ. Because of these side effects, aldesleukin only can be given to patients who are physically and mentally able to tolerate them. Most of the side effects are due to "capillary leak" which begins immediately after treatment is started. Capillary leak results in the leakage of proteins out of blood. This causes a loss of fluid from the blood, a decrease in the volume of blood, and a decrease in blood pressure. The decrease in blood pressure can be dramatic and even result in death. More than two-thirds of patients require injectable medications to treat the low blood pressure. Other problems associated with capillary leak include congestion in the lungs, difficulty breathing (which can occur in one-half of patients), wheezing, respiratory failure (1 out of every 11 patients), and swelling due to fluid accumulation in various tissues in the body (half of all patients). Abnormal heart rhythms occur in 1 out of every 12 patients, and heart attacks in 1 out of every 50. Bleeding from the stomach, intestines, and kidney or liver damage also can occur. Moreover, between two-thirds and three-fourths of all patients receiving aldesleukin develop kidney damage. Most of the side effects caused by capillary leak begin to resolve a few hours after stopping aldesleukin therapy.

Source: http://www.medicinenet.com

Yes

Source: http://www.medicinenet.com

Vials containing 22 million IU (international units) of aldesleukin as a lyophilized (freeze-dried) powder, with diluent.

Source: http://www.medicinenet.com

The vials should be stored in a refrigerator at 2 C to 8 C (36 F to 46 F ) before and after reconstitution with diluent. The vials should not be frozen. The solution should be brought to room temperature prior to infusion and used within 48 hours of reconstitution. Since the vials do not contain a preservative, any unused portion must be discarded.

Source: http://www.medicinenet.com

The recommended dose is 600,000 IU/kg intravenously over 15 minutes every 8 hours for 14 doses followed by 9 days of rest then another 14 doses.

Source: http://www.medicinenet.com

It is not known whether aldesleukin can cause harm to the fetus. Because of it known side effects, the manufacturer recommends that it only be given to pregnant women using extreme caution.

Source: http://www.medicinenet.com

It is not known whether aldesleukin is excreted in breast milk. Because of it known side effects, the manufacturer recommends that it only be given to pregnant women using extreme caution.

Source: http://www.medicinenet.com

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