Drug: allopurinol

Common reactions include diarrhea, nausea, rash and itching, and drowsiness. The most frequent side effect to allopurinol is skin rash. Allopurinol should be discontinued immediately at the first appearance of rash, painful urination, blood in the urine, eye irritation, or swelling of the mouth or lips, because these can be a signs of an impending severe allergic reaction that can be fatal. Allopurinol should be avoided by patients with a prior severe reaction to the drug. Allopurinol can cause a flare-up of gouty arthritis during initial therapy. Therefore, colchicine often is used simultaneously to prevent these flares. Rarely, allopurinol can cause nerve, kidney, and bone marrow damage. Allopurinol can cause a serious allergic liver toxicity that can be fatal. Appetite loss and itching can be signs of liver toxicity. The risk of this reaction increases in patients with kidney impairment. Patients with kidney impairment should receive lower doses of allopurinol.REFERENCE: FDA Prescribing Information

Source: http://www.medicinenet.com

Yes

Source: http://www.medicinenet.com

Tablets: 100, 300 mg; Powder for injection: 500 mg

Source: http://www.medicinenet.com

Tablets should be stored at room temperature between 15 C to 25 C (59 F to 77 F) and in a moisture proof, light- resistant container. Powder should be stored from 20 C to 25 C (68 F to 77 F) and not refrigerated.

Source: http://www.medicinenet.com

The dose of allopurinol for treating gout is 200-600 mg daily depending on severity. The dose for treating high uric acid blood levels due to chemotherapy is 100-800 mg daily starting 1 or 2 days before chemotherapy. It should be taken with food to avoid irritation of the stomach. In order to avoid formation of kidney stones, patients should drink plenty of fluids while taking allopurinol.

Source: http://www.medicinenet.com

There are no adequate studies of allopurinol in pregnant women.

Source: http://www.medicinenet.com

Allopurinol is excreted in breast milk. To avoid adverse effects in the infant, nursing mothers taking allopurinol should consider not breastfeeding.

Source: http://www.medicinenet.com

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