Drug: saquinavir

The most frequent side effects are headache, weakness, diarrhea, nausea and stomach discomfort. Saquinavir also may cause skin reactions, liver failure, seizures and failure of the pancreas (pancreatitis). Like other protease inhibitors, use of saquinavir may be associated with redistribution or accumulation of body fat, increased cholesterol and worsening of diabetes.Reference: FDA Prescribing Information
Last Editorial Review: 8/12/2011

Source: http://www.medicinenet.com

Yes

Source: http://www.medicinenet.com

Tablets: 500 mg; Capsules: 200 mg

Source: http://www.medicinenet.com

Store Invirase capsules at room temperature, 15-30 C (59-86 F).

Source: http://www.medicinenet.com

The recommended dose of Invirase for adults is 600 mg three times daily. Invirase should be administered within 2 hours of a meal.

Source: http://www.medicinenet.com

Saquinavir interacts with many drugs. Some of the important interactions are mentioned below. Viewers should consult their health care provider before combining any drugs with saquinavir. Saquinavir should not be used together with triazolam (Halcion), midazolam (Versed), sildenafil (Viagra) and ergotamine derivatives (for example, Ergostat) because saquinavir increases the concentration of these drugs in the body and this could cause serious side effects. Saquinavir also may inhibit the break-down of the cholesterol-lowering drugs lovastatin (Mevacor), simvastatin (Zocor), atorvastatin (Lipitor) and cerivastatin (Baycol). Combining saquinavir with these drugs may increase the occurrence of muscle breakdown (rhabdomyolysis) which is seen when these drugs accumulate in the body. Clarithromycin (Biaxin) and ketoconazole (Nizoral) may increase blood concentrations of saquinavir and cause increased severity or frequency of side effects from saquinavir. Saquinavir also increases the concentration of clarithromycin. Rifampin (Rifadin) and rifabutin (Mycobutin) decrease blood concentrations of saquinavir and therefore could decrease the effectiveness of saquinavir.

Source: http://www.medicinenet.com

Use of saquinavir during pregnancy has not been adequately evaluated.

Source: http://www.medicinenet.com

It is not known whether saquinavir is secreted in breast milk. Nevertheless, HIV-infected mothers should not breast-feed because of the potential risk of transmitting HIV to an infant that is not infected.

Source: http://www.medicinenet.com

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