Side effects of amlodipine are generally mild and reversible. The two most common side effects are:
- headache and
- edema (swelling) of the lower extremities.
Less common side effects include:
- nausea, and
In patients with severe coronary artery disease, amlodipine can increase the frequency and severity of angina or actually cause a heart attack on rare occasions. This phenomenon usually occurs when first starting amlodipine, or at the time of an increase in dosage. Excessive lowering of blood pressure during initiation of amlodipine treatment can occur, especially in patients already taking other medications that lower blood pressure. In rare instances, congestive heart failure has been associated with amlodipine, usually in patients already taking a beta blocker.