Drug: amprenavir

The most frequent side effects are headache, weakness, diarrhea, nausea and stomach pain. Amprenavir may also cause severe skin reactions and breakdown of red blood cells. The propylene glycol in the oral solution can cause seizures, stupor, increased heart rate, metabolic disturbance, and kidney failure. Like other protease inhibitors, use of amprenavir may be associated with redistribution or accumulation of body fat, increased cholesterol and worsening of diabetes. Reference: FDA Prescribing Information
Last Editorial Review: 11/15/2012

Source: http://www.medicinenet.com

Yes

Source: http://www.medicinenet.com

Capsule: 50 and 150 mg; Solution: 15 mg/ml

Source: http://www.medicinenet.com

Capsules and oral solution should be stored at room temperature, 20 C to 25 C (68 F to 77 F).

Source: http://www.medicinenet.com

The recommended dose is based on age, weight and the formulation. Individuals 4-12 years old or 13-16 years old and weighing less than 50 kg should receive 22.5 mg/kg twice daily or 17 mg/kg three times daily of the oral solution or 20 mg/kg twice daily or 15 mg/kg three times daily of the capsules. Individuals 13- 16 years old who weigh 50 kg or more and individuals older than 16 years of age should receive 1400 mg twice daily of the oral solution or 1200 mg twice daily of the capsules. The maximum daily dose is 2800 mg. Amprenavir capsules and solution are not interchangeable milligram for milligram. The oral solution should only be used when it is not possible to administer the capsules. Amprenavir can be taken with or without food. However, foods high in fat may decrease the absorption of amprenavir and should be avoided.

Source: http://www.medicinenet.com

It is not known whether amprenavir is secreted in breast milk. Nevertheless, HIV-infected mothers should not breast-feed because of the potential risk of transmitting HIV to an infant that is not infected.

Source: http://www.medicinenet.com

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