Drug: apremilast

The most common side effects associated with apremilast are diarrhea, nausea, and headache. It also can cause upper respiratory tract infections. Depression, upper abdominal pain, and weight loss were also reported in clinical studies. REFERENCE: FDA Prescribing Information.

Source: http://www.medicinenet.com

Yes

Source: http://www.medicinenet.com

Tablets: 10, 20, and 30 mg

Source: http://www.medicinenet.com

Apremilast tablets should be stored at room temperature below 30 C (86 F).

Source: http://www.medicinenet.com

Apremilast tablets should be swallowed whole and should not be broken, chewed or crushed before swallowing. Apremilast tablets can be taken with or without food. Treatment is started with a 14-day starter pack. The starting dose is 10 mg taken on the first day. The dose is gradually increased for 5 days until the recommended dose of 30 mg twice a day is reached.
  • Day 1: 10 mg in the morning
  • Day 2: 10 mg in the morning and 10 mg in the evening
  • Day 3: 10 mg in the morning and 20 mg in the evening
  • Day 4: 20 mg in the morning and 20 mg in the evening
  • Day 5: 20 mg in the morning and 30 mg in the evening
  • Day 6 and thereafter: 30 mg twice a day
After the starter pack is complete, the rest of the tablets will be supplied by a specialty pharmacy. The recommended dose long term dose is 30 mg twice a day. Patients with renal failure should have only a maximum of 30 mg per day; pm doses should be skipped.

Source: http://www.medicinenet.com

It is not known whether apremilast is secreted into breast milk.

Source: http://www.medicinenet.com

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