The most common side effects are application site reactions such as itching, blisters, and redness. Other side effects include:
- acne, enlarged breasts,
- high blood pressure,
- mood swings,
- changes in libido,
- increased serum prostate specific antigen (PSA) levels, and
- increased volume of red blood cells.
Other important side effects include:
- Reduced sperm production,
- prolonged painful erection,
- enlarged prostate,
- depression, and
- worsening of heart failure also occur.