Drug: tocilizumab

The most common adverse effects of tocilizumab in clinical studies were respiratory tract infections, headaches, hypertension (high blood pressure), and elevations in liver tests suggesting liver injury. Injection site reactions (rash, redness, swelling, itching) may also occur. Use of tocilizumab has been associated with serious infections such as tuberculosis, sepsis (bacteria in the blood) and fungal infections. Individuals with active infections should not be treated with tocilizumab. Tocilizumab may worsen or cause new diseases of the nervous system. In studies, some patients who used tocilizumab developed cancer. Other side effects include reduced levels of white blood cells or platelets, reactivation of herpes zoster infection (shingles), and hypersensitivity (allergic) reactions. In studies, gastrointestinal perforation was observed in patients with diverticulitis. REFERENCE: FDA prescribing information for Actemra
Last Editorial Review: 9/13/2010 12:02:36 PM

Source: http://www.medicinenet.com

Yes

Source: http://www.medicinenet.com

Injection: 20 mg/ml

Source: http://www.medicinenet.com

Tocilizumab should be stored refrigerated at 2 to 8 C (36 to 46 F).

Source: http://www.medicinenet.com

The recommended dose of tocilizumab is 4-8 mg/kg administered as a single 60 minute intravenous infusion every 4 weeks.

Source: http://www.medicinenet.com

Tocilizumab has not been studied in combination with other similar drugs that block other chemicals that promote inflammation, for example, drugs that block TNF (for example, adalimumab  [Humira]). Combining anakinra (Kineret), abatacept (Orencia), rituximab (Rituxan) with other antirheumatic drugs similar to tocilizumab resulted in a reduction in white blood cells in the blood (neutropenia), serious infections and no additional benefit. Tocilizumab may interfere with the effectiveness of vaccines. Live vaccines, including attenuated vaccines, should not be given to patients receiving tocilizumab.

Source: http://www.medicinenet.com

There are no adequate studies of tocilizumab in pregnant women.

Source: http://www.medicinenet.com

It is not known whether tocilizumab is excreted in breast milk.

Source: http://www.medicinenet.com

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