Trizivir causes the same side effect as its component drugs, abacavir, lamivudine and zidovudine. The most common side effects are:
- weight loss, and
- difficulty sleeping.
Serious and sometimes fatal hypersensitivity reactions involving several organs have been associated with abacavir, a component of Trizivir. Symptoms include fever, rash, nausea, vomiting, diarrhea, abdominal pain, fatigue, aches, shortness of breath, cough, and sore throat. Patients should discontinue Trizivir if a hypersensitivity reaction is suspected. Patients who carry a certain genetic marker called HLA-B 5701 are at high risk for experiencing a hypersensitivity reaction to abacavir. Screening for the HLA-B 5701 allele is recommended prior to initiating therapy with abacavir. Other important side effects of the abacavir component include:
- liver failure
- metabolic disturbance (lactic acidosis)
- decrease in blood cells,
- muscle pain
- weakness and nerve damage in the extremities (peripheral neuropathy).