Drug: abacavir, lamivudine, zidovudine

Trizivir causes the same side effect as its component drugs, abacavir, lamivudine and zidovudine. The most common side effects are:
  • nausea,
  • diarrhea,
  • vomiting,
  • weight loss, and
  • difficulty sleeping.
Serious and sometimes fatal hypersensitivity reactions involving several organs have been associated with abacavir, a component of Trizivir. Symptoms include fever, rash, nausea, vomiting, diarrhea, abdominal pain, fatigue, aches, shortness of breath, cough, and sore throat. Patients should discontinue Trizivir if a hypersensitivity reaction is suspected. Patients who carry a certain genetic marker called HLA-B 5701 are at high risk for experiencing a hypersensitivity reaction to abacavir. Screening for the HLA-B 5701 allele is recommended prior to initiating therapy with abacavir. Other important side effects of the abacavir component include:
  • pancreatitis,
  • liver failure
  • metabolic disturbance (lactic acidosis)
  • decrease in blood cells,
  • muscle pain
  • weakness and nerve damage in the extremities (peripheral neuropathy).

Source: http://www.medicinenet.com

Yes.

Source: http://www.medicinenet.com

Tablets: 300 mg abacavir/150 mg lamivudine/300 mg zidovudine.

Source: http://www.medicinenet.com

Capsules and powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

Source: http://www.medicinenet.com

The recommended dose for adults and adolescents is one tablet twice daily.

Source: http://www.medicinenet.com

Use of Trizivir by nursing women has not been adequately studied. Nevertheless, HIV-infected mothers should not breastfeed because of the potential risk of transmitting HIV to an infant that is not infected. Medically reviewed by Eni Williams, PharmDReference: FDA Prescribing Information

Source: http://www.medicinenet.com

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